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When either morphine or naloxone was administered alone, the overall response rate decreased with increasing doses. The rate\u2010decreasing effect was accompanied by an increase in percent errors with morphine but not with naloxone. Both effects of morphine were antagonized by doses of naloxone that were ineffective when given alone. The antagonism was selective in that naloxone (3 mg\/kg) completely blocked the error\u2010increasing effect but not the rate\u2010decreasing effect of the higher doses of morphine. The view that naloxone is a specific narcotic antagonist was supported by the finding that naloxone failed to antagonize the rate\u2010decreasing and error\u2010increasing effects of <jats:italic>d<\/jats:italic>\u2010amphetamine, pentobarbital, and phencyclidine.<\/jats:p>","DOI":"10.1901\/jeab.1981.36-371","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T17:04:16Z","timestamp":1141319056000},"page":"371-380","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["SELECTIVE ANTAGONISM OF THE ERROR\u2010INCREASING EFFECT OF MORPHINE BY NALOXONE IN A REPEATED\u2010ACQUISITION TASK"],"prefix":"10.1002","volume":"36","author":[{"given":"Donald M.","family":"Thompson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"Moerschbaecher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"33","article-title":"Behavior as a stimulus: Joint effects of d\u2010amphetamine and pentobarbital","volume":"189","author":"Branch M. 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