{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T22:41:07Z","timestamp":1697928067457},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":9859,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exper Analysis Behavior"],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:p>Effects of chlorpromazine (1 to 100 mg\/kg) were assessed on two pigeons' responding under various modifications of a multiple schedule of food delivery. During a fixed\u2010interval component, the first response after 5 min produced food; during the subsequent, fixed\u2010ratio component, the 30th response produced food. Modifications of the schedule entailed changes in stimulus conditions imposed during the fixed\u2010ratio component that did not systematically alter characteristics of performance under non\u2010drug conditions. In the first phase of the experiment, distinctive visual stimuli were correlated with each schedule component (conventional multiple schedule); chlorpromazine produced small decreases in fixed\u2010ratio responding (20% at 30 mg\/kg). When each response during the fixed\u2010ratio component produced the stimulus correlated with the fixed\u2010interval schedule (fixed\u2010interval discriminative stimulus) for 1.2 s, effects of chlorpromazine were not different from those under the conventional multiple schedule. Chlorpromazine produced greater decreases in fixed\u2010ratio responding (55% at 30 mg\/kg) when either the first response of each fixed ratio changed the stimulus correlated with the fixed\u2010ratio schedule to the fixed\u2010interval discriminative stimulus for the remainder of the fixed\u2010ratio component, or when the fixed\u2010interval discriminative stimulus was presented independently of responding according to a matched temporal sequence. When the fixed\u2010interval discriminative stimulus was present continuously during the fixed\u2010ratio component (mixed schedule), chlorpromazine produced even more substantial decreases in fixed\u2010ratio responding (greater than 80% at 30 mg\/kg). Effects of chlorpromazine on fixed\u2010interval responding were also modified by the schedules of fixed\u2010interval discriminative stimulus presentation. The effects of chlorpromazine were a joint function of the stimuli prevailing during the multiple schedule and the degree to which responding influenced these stimuli.<\/jats:p>","DOI":"10.1901\/jeab.1986.45-195","type":"journal-article","created":{"date-parts":[[2006,3,3]],"date-time":"2006-03-03T19:41:14Z","timestamp":1141414874000},"page":"195-205","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["EFFECTS OF CHLORPROMAZINE ON FIXED\u2010RATIO RESPONDING: MODIFICATION BY FIXED\u2010INTERVAL DISCRIMINATIVE STIMULI"],"prefix":"10.1002","volume":"45","author":[{"given":"Jeffrey M.","family":"Witkin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00432291"},{"key":"e_1_2_1_3_1","first-page":"139","volume-title":"Advances in behavioral pharmacology","author":"Appel J. 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