{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T12:18:59Z","timestamp":1700396339750},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2013,2,26]],"date-time":"2013-02-26T00:00:00Z","timestamp":1361836800000},"content-version":"vor","delay-in-days":4805,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Exper Analysis Behavior"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p>Eight rats were trained to discriminate pentobarbital from saline under a concurrent variable\u2010interval (VI) VI schedule, on which responses on the pentobarbital\u2010biased lever after pentobarbital were reinforced under VI 20 s and responses on the saline\u2010biased lever were reinforced under VI 80 s. After saline, the reinforcement contingencies programmed on the two levers were reversed. The rats made 62.3% of their responses on the pentobarbital\u2010biased lever after pentobarbital and 72.2% on the saline\u2010biased lever after saline, both of which are lower than predicted by the matching law. When the schedule was changed to concurrent VI 50 s VI 50 s for test sessions with saline and the training dose of pentobarbital, responding on the pentobarbital\u2010biased lever after the training dose of pentobarbital and on the saline\u2010biased lever after saline became nearly equal, even during the first 2 min of the session, suggesting that the presence or absence of the training drug was exerting minimal control over responding and making the determination of dose\u2014effect relations of drugs difficult to interpret. When the pentobarbital dose\u2014response curve was determined under the concurrent VI 50\u2010s VI 50\u2010s schedule, responding was fairly evenly distributed on both levers for most rats. Therefore, 6 additional rats were trained to respond under a concurrent VI 60\u2010s VI 240\u2010s schedule. Under this schedule, the rats made 62.6% of their responses on the pentobarbital\u2010biased lever after pentobarbital and 73.5% of their responses on the saline\u2010biased lever after saline, which also is lower than the percentages predicted by perfect matching. When the schedule was changed to a concurrent VI 150\u2010s VI 150\u2010s schedule for 5\u2010min test sessions with additional drugs, the presence or absence of pentobarbital continued to control responding in most rats, and it was possible to generate graded dose\u2014response curves for pentobarbital and other drugs using the data from these 5\u2010min sessions. The dose\u2014response curves generated under these conditions were similar to the dose\u2014response curves generated using other reinforcement schedules and other species.<\/jats:p>","DOI":"10.1901\/jeab.2000.73-103","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T16:42:55Z","timestamp":1141317775000},"page":"103-120","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["DRUG DISCRIMINATION IN RATS UNDER CONCURRENT VARIABLE\u2010INTERVAL VARIABLE\u2010INTERVAL SCHEDULES"],"prefix":"10.1002","volume":"73","author":[{"given":"D. E.","family":"McMillan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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