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Dexfenfluramine decreased food intake under both conditions, but the doses required to decrease intake under free\u2010access conditions were higher than those required to reduce intake under the PR condition. Intermediate doses of phentermine sometimes increased breaking points, and higher doses decreased them. Phentermine decreased food intake at the same doses under both access conditions. Thus the potency of dexfenfluramine, but not phentermine, to decrease food\u2010maintained behavior depended upon the food\u2010access condition. Experiment 2 used a novel mixed progressive\u2010ratio schedule of food delivery to study the duration of drug effects. Sessions consisted of five components separated by 3\u2010hr timeouts. The ratio requirement reset at the beginning of each component and a new breaking point was obtained. Both dexfenfluramine and phentermine dose\u2010dependently decreased breaking points early in the session. In some rats, compensatory increases in breaking point were observed. That is, breaking points later in the session increased over control levels, resulting in no change in the total number of food pellets earned for the session compared to control. The present findings suggest that the effects of some anorectic drugs depend upon the access conditions for food; increasing the effort to obtain food may enhance their ability to decrease food\u2010maintained behavior.<\/jats:p>","DOI":"10.1901\/jeab.2004.82-275","type":"journal-article","created":{"date-parts":[[2006,3,2]],"date-time":"2006-03-02T16:42:55Z","timestamp":1141317775000},"page":"275-292","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["EFFECTS OF ANORECTIC DRUGS ON FOOD INTAKE UNDER PROGRESSIVE\u2010RATIO AND FREE\u2010ACCESS CONDITIONS IN RATS"],"prefix":"10.1002","volume":"82","author":[{"given":"Mark G.","family":"Le Sage","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Stafford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Glowa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2013,2,26]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.2165\/00129784-200202040-00004"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6989(82)80025-8"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1981.tb09142.x"},{"key":"e_1_2_1_5_1","first-page":"15","article-title":"Species differences in the kinetics and metabolism of fenfluramine isomers","volume":"258","author":"Caccia S.","year":"1982","journal-title":"Archives Internationales de Pharmacodynamie et de Therapie"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(00)00431-7"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.102.3.441"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600620922"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(79)90262-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428117"},{"key":"e_1_2_1_11_1","first-page":"101","article-title":"Effects of anorectic drugs on the topography of feeding behavior in baboons","volume":"249","author":"Foltin R. 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