{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T02:12:51Z","timestamp":1790993571523,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Periodontol"],"published-print":{"date-parts":[[2000,12]]},"abstract":"\n Background:<\/jats:bold>\n While the use of hydroxyapatite (HA)\u2010coated endosseous dental implants has gained in popularity over the past 10 years, the short\u2010term and long\u2010term predictability and indications for their use remain highly controversial. Some reports suggest that the HA coating may separate from the substructure, undergo dissolution in tissue fluids, and\/or contribute to rapid osseous breakdown around the implant. Other reports, however, relate favorable responses to HA\u2010coated implants, which include rapid bone adaptation to the HA, greater stability at uncovering, and increased coronal bone growth. These contradictions may be related to differences in chemical composition of the HA on the implant surface. Most clinicians and researchers may agree that long\u2010term, independent, scientific clinical studies are needed to compare HA\u2010coated and non\u2014HA\u2010coated (titanium\u2010alloy and CP\u2010titanium) implants under the same conditions. Concerns appear in the literature that HA\u2010coated implants experience greater breakdown because they are more susceptible to bacterial colonization due to their roughness and hydrophilicity. Some studies suggest that specific putative periodontal pathogens may adhere to the HA, thereby predisposing the implant to greater peri\u2010implantitis than that experienced by non\u2010HA implants.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n A total of 32 clinical research centers, located in various geographic regions of the United States, were selected to participate in a comprehensive clinical study. More than 2,900 HA\u2010coated and non\u2010 HA implants were randomized as to location within one of three jaw regions\u2014maxillary anterior, mandibular anterior, and mandibular posterior\u2014and followed for 36 months. It can be assumed that in each of these jaw regions, the conditions associated with both implant surface types would be similar enough to permit meaningful comparisons of periodontal\u2010type measurements that have not previously been reported. Periodontal\u2010 type measurements (gingiva, plaque, suppuration, and calculus indices; probing depth; attachment levels; recession; and keratinized tissue width) for each aspect of each implant (mesial, facial, distal, and lingual) were recorded at 3, 6, 9, 12, 18, 24, and 36 months following implant uncovering. The implant was considered the experimental unit for analysis using generalized estimating equation and repeated measure methods. Data for the four aspects of each implant, as well as measurements over time, were all clustered in the unit of analysis.\n <\/jats:p>\n \n Results:<\/jats:bold>\n The percentages of implants with zeros recorded for the indices was remarkably similar for both HA\u2010coated and non\u2010HA implants. While statistically significant differences were found for some of the measurements associated with HA\u2010coated and non\u2010HA implants under certain conditions, these differences were too small to be considered clinically significant.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n Overall, there was no clinically significant difference between the periodontal\u2010type measurements for HA\u2010coated and non\u2014HA\u2010coated implants followed for a period from 3 through 36 months. The concerns about HA\u2010coated implants being associated with adverse periodontal responses for the HA chemical composition included in this study appear to be unfounded for a period of clinical performance up to 36 months.\n Ann Periodontol 2000;5:56\u201067.<\/jats:italic>\n <\/jats:p>","DOI":"10.1902\/annals.2000.5.1.56","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T05:47:03Z","timestamp":1107323223000},"page":"56-67","source":"Crossref","is-referenced-by-count":60,"title":["Periodontal\u2010Type Measurements Associated With Hydroxyapatite\u2010Coated and Non\u2014HA\u2010Coated Implants: Uncovering to 36 Months"],"prefix":"10.1002","volume":"5","author":[{"given":"Harold F.","family":"Morris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Ochi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Robert","family":"Spray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,12]]},"container-title":["Annals of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/annals.2000.5.1.56","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:46:36Z","timestamp":1762361196000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/annals.2000.5.1.56"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,12]]}},"alternative-id":["10.1902\/annals.2000.5.1.56"],"URL":"https:\/\/doi.org\/10.1902\/annals.2000.5.1.56","archive":["Portico"],"relation":{},"ISSN":["1553-0841","2162-5131"],"issn-type":[{"value":"1553-0841","type":"print"},{"value":"2162-5131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}