{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:02Z","timestamp":1787023742052,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ann Periodontol"],"published-print":{"date-parts":[[2002,12]]},"abstract":"<jats:p>\n                    Periodontitis is a bacterially induced chronic inflammatory disease and a major cause of tooth loss in the world. The tissue damage and alveolar bone resorption characteristic of the disease are believed to be due to a destructive innate host response to a pathogenic subgingival biofilm.\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    , a Gram\u2010negative bacterium, is a member of this mixed microbial community that has been designated an etiologic agent of periodontitis. The innate host response to lipopolysaccharide (LPS) obtained from\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    is unusual in that different studies have reported that it can be an agonist for Toll\u2010like receptor (TLR) 2 as well as an antagonist or agonist for TLR4. In addition, human monocytes respond to this LPS by secreting a variety of different inflammatory mediators, while endothelial cells do not. We have examined highly purified preparations of\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    LPS and found that they activate both TLR2 combined with TLR1 and TLR4 in transiently transfected human embryonic kidney (HEK) 293 cells. We have further demonstrated that highly purified\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    LPS preparations contain at least 3 major different lipid A species. We speculate that\n                    <jats:italic>P. gingivalis<\/jats:italic>\n                    lipid A structural heterogeneity contributes to the unusual innate host response to this LPS and its ability to interact with different TLR molecules.\n                    <jats:italic>Ann Periodontol 2002;7:29\u201037.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/annals.2002.7.1.29","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T05:51:29Z","timestamp":1107323489000},"page":"29-37","source":"Crossref","is-referenced-by-count":59,"title":["<i>Porphyromonas gingivalis<\/i>\n                    Lipopolysaccharide Displays Functionally Diverse Interactions With the Innate Host Defense System"],"prefix":"10.1002","volume":"7","author":[{"given":"Brian W.","family":"Bainbridge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen R.","family":"Coats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Darveau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,12]]},"container-title":["Annals of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/annals.2002.7.1.29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T09:35:25Z","timestamp":1762335325000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/annals.2002.7.1.29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["10.1902\/annals.2002.7.1.29"],"URL":"https:\/\/doi.org\/10.1902\/annals.2002.7.1.29","archive":["Portico"],"relation":{},"ISSN":["1553-0841","2162-5131"],"issn-type":[{"value":"1553-0841","type":"print"},{"value":"2162-5131","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}