{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:56:00Z","timestamp":1760043360030,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":2057,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Recession defects are typically characterized by loss of periodontal attachment, including gingiva, periodontal ligament, alveolar bone, and cementum. Numerous techniques have been developed for treatment of these defects using soft\u2010tissue grafting procedures with autogenous and allograft materials that generally heal with root coverage and repair of the defects. This case presentation illustrates a technique using a particulate carrier saturated with recombinant human platelet\u2010derived growth factor\u2010BB (rhPDGF\u2010BB) and coronally advanced gingival flaps to cover recession defects. Additionally, other scientific evidence from previous studies suggests that this technique may lead to periodontal regeneration, including cementum, periodontal ligament, and alveolar bone over previously exposed roots, which might be preferable to other methods that lead to periodontal repair.<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> This article illustrates a technique to coronally position flaps in combination with rhPDGF\u2010BB\u2010saturated particulate graft material. Results show significant root coverage with excellent color and texture match to adjacent tissues. Additionally, the alveolus appeared thicker than non\u2010treated areas, suggesting appositional augmentation of the sites. Human histologic investigation of this technique in other studies confirms that periodontal regeneration can occur with this technique.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Coronally positioned flaps over rhPDGF\u2010BB\u2010soaked human freeze\u2010dried bone allograft, termed \u201crecession regeneration,\u201d can result in significant root coverage with excellent esthetics, even in demanding cases. Surgical reentry of one case shows significant regeneration of buccal alveolar bone over the previously exposed root surfaces, consistent with periodontal regeneration that is not ordinarily observed with other root coverage techniques unless biologic modifiers or cell occlusive barrier membranes are used.<\/jats:p>","DOI":"10.1902\/cap.2011.110024","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T05:45:44Z","timestamp":1334641544000},"page":"57-64","source":"Crossref","is-referenced-by-count":2,"title":["Regenerative Treatment for Recession Defects Using Purified Human Platelet\u2010Derived Growth Factor\u2010BB, Particulate Grafts, and Coronally Repositioned Flaps"],"prefix":"10.1002","volume":"2","author":[{"given":"Jeffrey","family":"Ganeles","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A","family":"Pette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.9.1588"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1999.tb00152.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.090540"},{"key":"e_1_2_8_5_1","first-page":"127","article-title":"Comparison of recombinant human platelet\u2010derived growth factor\u2010BB plus beta tricalcium phosphate and a collagen membrane to subepithelial connective tissue grafting for the treatment of recession defects: A case series","volume":"26","author":"McGuire MK","year":"2006","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_6_1","first-page":"7","article-title":"Evaluation of human recession defects treated with coronally advanced flaps and either purified recombinant human platelet\u2010derived growth factor\u2010BB with beta tricalcium phosphate or connective tissue: A histologic and microcomputed tomographic examination","volume":"29","author":"McGuire MK","year":"2009","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.080502"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.5.387"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.7.834"},{"key":"e_1_2_8_10_1","first-page":"8","article-title":"A classification of marginal tissue recession","volume":"5","author":"Miller PD","year":"1985","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.9.1282"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-051X.29.s3.11.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2003.8.1.303"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.12.1534"},{"key":"e_1_2_8_15_1","first-page":"269","article-title":"Clinical and histologic evaluation of human gingival recession treated with a subepithelial connective tissue graft and enamel matrix derivative (Emdogain): A case report","volume":"20","author":"Rasperini G","year":"2000","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090041"},{"issue":"5","key":"e_1_2_8_17_1","first-page":"861","article-title":"Parameter on mucogingival conditions","volume":"71","author":"American Academy of Periodontology","year":"2000","journal-title":"J Periodontol"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/cap.2011.110024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:59:53Z","timestamp":1760039993000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/cap.2011.110024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1902\/cap.2011.110024"],"URL":"https:\/\/doi.org\/10.1902\/cap.2011.110024","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}