{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T08:58:20Z","timestamp":1762505900880,"version":"build-2065373602"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,18]],"date-time":"2017-12-18T00:00:00Z","timestamp":1513555200000},"content-version":"vor","delay-in-days":2057,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Gingival overgrowth, with its potential cosmetic implications and for providing new niches for the growth of microorganisms, is a serious concern for both patients and clinicians. Amlodipine is a comparatively new calcium channel blocker and is being used with increasing frequency in the management of hypertension and angina. Although amlodipine is considered a safe drug, it may induce gingival overgrowth in some individuals.<\/jats:p><jats:p><jats:bold>Case Presentation<\/jats:bold>: A rare case of amlodipine\u2010induced gingival overgrowth in a 60\u2010year\u2010old Indian woman who was on amlodipine for 3 years and subsequent periodontal management of the overgrowth is reported here. The patient did not have any gingival overgrowth for 2 years despite the fact that she was taking amlodipine, but she developed the gingival overgrowth 9 months before her initial visit, coincident with uncontrolled diabetes mellitus and use of a cholesterol\u2010lowering drug. She was treated with drug substitution for the systemic condition and surgical treatment for the overgrowth. She was followed up for 1 year, regularly.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> We speculate that overgrowth could have been triggered by uncontrolled type 2 diabetes mellitus and by altered pharmacokinetics of amlodipine resulting from the drug interaction of amlodipine with a cholesterol\u2010lowering drug.<\/jats:p>","DOI":"10.1902\/cap.2012.110026","type":"journal-article","created":{"date-parts":[[2012,4,17]],"date-time":"2012-04-17T05:45:44Z","timestamp":1334641544000},"page":"115-122","source":"Crossref","is-referenced-by-count":3,"title":["Amlodipine\u2010Induced Gingival Overgrowth in a Patient With Uncontrolled Type 2 Diabetes Mellitus With Hypercholesterolemia: A Case Report"],"prefix":"10.1002","volume":"2","author":[{"given":"K.","family":"Smitha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,18]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"20","article-title":"Systemic drugs as a risk factor for periodontal disease initiation and progression","volume":"16","author":"Rees TD","year":"1995","journal-title":"Compendium"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1999.70.1.63"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92470-E"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb02072.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.2001.6.1.99"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-2391(88)90192-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2005.76.7.1217"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2008.080033"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.11.1323"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.2006.00171.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9236(98)90067-4"},{"key":"e_1_2_8_13_1","first-page":"179","article-title":"Mibefradil significantly increases serum concentrations of atorvastatin but not pravastatin","volume":"65","author":"Donahue S","year":"1999","journal-title":"Clin Pharmacol Ther"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(72)90228-9"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1992.63.5.453"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.4065\/73.12.1196"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2001.72.5.605"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1079-2104(05)80223-9"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1998.69.2.108"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.1993.28.6.396"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2005.02485.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.097001"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1997.68.11.1140"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(93)90027-2"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1979.tb02189.x"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/cap.2012.110026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:59:56Z","timestamp":1760039996000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/cap.2012.110026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1902\/cap.2012.110026"],"URL":"https:\/\/doi.org\/10.1902\/cap.2012.110026","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"type":"print","value":"2573-8046"},{"type":"electronic","value":"2163-0097"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}