{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:19:42Z","timestamp":1769210382142,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:00:00Z","timestamp":1509494400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Adv Periodontics"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:p><jats:bold>Introduction:<\/jats:bold> Aggressive periodontitis (AgP) is a form of periodontitis characterized by rapid attachment loss in otherwise healthy individuals. Although different treatment options have been explored for management of the disease, control of disease progression and subsequent regeneration of the attachment apparatus are considered the ideal treatment objectives. Limited evidence is available with respect to the efficacy of different regenerative materials in the treatment of AgP.<\/jats:p><jats:p><jats:bold>Case Presentation:<\/jats:bold> The present case report describes periodontal regeneration techniques and 6\u2010month outcomes in bilateral intrabony non\u2010contained defects around mandibular first molars in a 21\u2010year\u2010old patient diagnosed with localized AgP (LAgP). Periodontal lesions were treated with regenerative therapy with enamel matrix derivative (EMD) and allograft on the right side and allograft with bioabsorbable collagen membrane without EMD on the left side. Treatment yielded favorable clinical outcomes in terms of probing depth reduction, clinical attachment level gain, minimal gingival inflammation, and radiographic bone fill. Radiographic bone fill was observed after 6 months, suggesting possible periodontal regeneration.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Both regeneration techniques used in this clinical report (guided tissue regeneration involving allograft and bioabsorbable membrane versus EMD combined with allograft without a barrier membrane) resulted in favorable outcomes in the treatment of deep (\u22657 mm) non\u2010contained intrabony defects in LAgP.<\/jats:p>","DOI":"10.1902\/cap.2017.170007","type":"journal-article","created":{"date-parts":[[2017,5,15]],"date-time":"2017-05-15T00:30:59Z","timestamp":1494808259000},"page":"182-189","source":"Crossref","is-referenced-by-count":2,"title":["Treatment of Localized Aggressive Periodontitis With Guided Tissue Regeneration Technique and Enamel Matrix Derivative"],"prefix":"10.1002","volume":"7","author":[{"given":"Fatemeh","family":"Momen\u2010Heravi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1990.61.10.643"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060492"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.11s.1157"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01567.x"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2015.130685"},{"key":"e_1_2_9_8_1","first-page":"323","article-title":"GTR treatment of intrabony defects in patients with early\u2010onset and chronic adult periodontitis","volume":"22","author":"Zucchelli G","year":"2002","journal-title":"Int J Periodontics Restorative Dent"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-015-1608-z"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1972.43.1.38"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2002.73.6.675"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/535321"},{"key":"e_1_2_9_13_1","doi-asserted-by":"crossref","unstructured":"CorbellaS WeinsteinR FrancettiL TaschieriS Del FabbroM.Periodontal regeneration in aggressive periodontitis patients: A systematic review of the literature [published online ahead of print October 25 2016].J Investig Clin Dent. doi: 10.1111\/jicd.12245.","DOI":"10.1111\/jicd.12245"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12413"},{"key":"e_1_2_9_15_1","first-page":"247","article-title":"Enamel matrix derivative (Emdogain) for periodontal tissue regeneration in intrabony defects. A Cochrane systematic review","volume":"2","author":"Esposito M","year":"2009","journal-title":"Eur J Oral Implantol"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100144"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2008.01242.x"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513501878"}],"container-title":["Clinical Advances in Periodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/cap.2017.170007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:33:11Z","timestamp":1760045591000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/cap.2017.170007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1902\/cap.2017.170007"],"URL":"https:\/\/doi.org\/10.1902\/cap.2017.170007","archive":["Portico"],"relation":{},"ISSN":["2573-8046","2163-0097"],"issn-type":[{"value":"2573-8046","type":"print"},{"value":"2163-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}