{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:41:14Z","timestamp":1760920874896,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1981,5,1]],"date-time":"1981-05-01T00:00:00Z","timestamp":357523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1981,5]]},"abstract":"<jats:p>A<jats:sc>n hypothesis<\/jats:sc> is proposed relating the possible role of vitamin C deficiency as an etiologic factor contributing to periodontal disease in diabetes. The hypothesis is based upon the following: (1) transport of ascorbate across cell membranes may be impaired by glucose, but facilitated by insulin; (2) glucose utilization is significantly accelerated by sublethal concentrations of endotoxin; (3) endotoxin\u2010induced histamine sensitivity of tissue is enhanced by ascorbic deficiency; and (4) ascorbic acid deficiency alters mucosal barrier function. The interrelationship of these factors is discussed.<\/jats:p>","DOI":"10.1902\/jop.1981.52.5.251","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T16:06:57Z","timestamp":1332346017000},"page":"251-254","source":"Crossref","is-referenced-by-count":10,"title":["Diabetes and Periodontal Disease \u2010\u2010 Possible Role of Vitamin C Deficiency: An Hypothesis"],"prefix":"10.1002","volume":"52","author":[{"given":"Joseph J.","family":"Aleo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1981,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1981.52.5.251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:44:13Z","timestamp":1760881453000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1981.52.5.251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1981,5]]}},"alternative-id":["10.1902\/jop.1981.52.5.251"],"URL":"https:\/\/doi.org\/10.1902\/jop.1981.52.5.251","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1981,5]]}}}