{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:01:59Z","timestamp":1762340519725,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[1982,12,1]],"date-time":"1982-12-01T00:00:00Z","timestamp":407548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1982,12]]},"abstract":"<jats:p>H<jats:sc>umoral igG, igA and igM<\/jats:sc> responses to three typed oral strains of <jats:italic>F. nucleatum<\/jats:italic> were examined in patients with chronic periodontitis and in individuals with clinically healthy gingiva. Attempts were made to isolate <jats:italic>F<\/jats:italic>. <jats:italic>nucleatum<\/jats:italic> from either the pathologic gingival crevices or healthy sulci in this study. Higher levels of IgG and IgA reactive to all three strains were observed in the chronic periodontitis patients; however, there were no differences between the IgM levels in the diseased and healthy individuals. Immunodiffusion studies with rabbit antiserum and adsorption studies of the human sera demonstrated a sharing of antigenic determinants by the <jats:italic>F<\/jats:italic>. <jats:italic>nucleatum<\/jats:italic> strains. <jats:italic>F<\/jats:italic>. <jats:italic>nucleatum<\/jats:italic> strains were isolated from 14 of the 15 individuals in the study.<\/jats:p>","DOI":"10.1902\/jop.1982.53.12.762","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T15:43:42Z","timestamp":1332344622000},"page":"762-766","source":"Crossref","is-referenced-by-count":20,"title":["The ELISA System for Measuring Antibody Reactive to <i>Fusobacterium nucleatum<\/i> in the Sera of Patients with Chronic Periodontitis"],"prefix":"10.1002","volume":"53","author":[{"suffix":"Jr.","given":"William A.","family":"Falkler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack W.","family":"Vincent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry","family":"Dober","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol","family":"Spiegel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Hayduk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1982,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1982.53.12.762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:48:05Z","timestamp":1760867285000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1982.53.12.762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1982,12]]}},"alternative-id":["10.1902\/jop.1982.53.12.762"],"URL":"https:\/\/doi.org\/10.1902\/jop.1982.53.12.762","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1982,12]]}}}