{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:51:17Z","timestamp":1791841877877,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1983,10,1]],"date-time":"1983-10-01T00:00:00Z","timestamp":433814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1983,10]]},"abstract":"<jats:p>S<jats:sc>everal antibiotics were found<\/jats:sc> to adsorb to saliva\u2010coated enamel and to inhibit <jats:italic>in vitro<\/jats:italic> plaque formation by pure cultures of oral bacteria: <jats:italic>Actinomyces viscosus, Actinomyces naeslundii<\/jats:italic> and <jats:italic>Streptococcus mutans.<\/jats:italic> Tetracycline, minocycline and oxytetracycline adsorbed to the greatest degree, showing 100\u2010fold higher adsorption than spiramycin, the test antibiotic with least adsorption. Inhibition of <jats:italic>in vitro<\/jats:italic> plaque formation was found to require both drug substantivity (capacity for adsorption) and antimicrobial activity. Inhibition of plaque formation in the <jats:italic>in vitro<\/jats:italic> assay employed correlated well with clinical efficacy.<\/jats:p>","DOI":"10.1902\/jop.1983.54.10.580","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T12:17:06Z","timestamp":1332332226000},"page":"580-585","source":"Crossref","is-referenced-by-count":107,"title":["Tetracycline and Its Derivatives Strongly Bind to and Are Released From the Tooth Surface in Active Form"],"prefix":"10.1002","volume":"54","author":[{"given":"P. J.","family":"Baker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. T.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"Coburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Genco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1983,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1983.54.10.580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:20:55Z","timestamp":1760869255000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1983.54.10.580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1983,10]]}},"alternative-id":["10.1902\/jop.1983.54.10.580"],"URL":"https:\/\/doi.org\/10.1902\/jop.1983.54.10.580","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,10]]}}}