{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:41:40Z","timestamp":1791416500971,"version":"4.3.3"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1984,3,1]],"date-time":"1984-03-01T00:00:00Z","timestamp":446947200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1984,3]]},"abstract":"<jats:p>C<jats:sc>ertain human lymphocyte antigen<\/jats:sc> (HLA) haplotypes have been correlated with the presence of certain diseases. To date no significant relationship between periodontitis and HLA haplotype has been demonstrated. The purpose of this study was to determine the frequency of HLA\u2010A, HLA\u2010B and HLA\u2010C haplotypes in patients resistant to chronic periodontitis and to determine if there is any association between specific HLA genes and periodontal health. Twenty\u2010five healthy individuals who demonstrated a high resistance to periodontal disease (mean age 49.9 years) were matched to 25 subjects with chronic periodontitis and to a periodontally undiagnosed population of 22,000 individuals. Peripheral blood was taken and HLA specificity was determined by the microlymphocytotoxicity test. The results indicated a statistically significant increase in the occurrence of HLA\u2010B5 (<jats:italic>P<\/jats:italic> = 0.0059) and a trend in the occurrence of HLA\u2010A28 (<jats:italic>P<\/jats:italic>= 0.0565) in those patients resistant to periodontal disease when compared to the matched controls. When compared to the large random control group, a significant correlation was observed for HLA\u2010A28 (<jats:italic>P<\/jats:italic> &lt; 0.01) in blacks and HLA\u2010B5 (<jats:italic>P<\/jats:italic> &lt; 0.01) in whites. It is possible that the HLA\u2010A28 and the HLA\u2010B5 individual may have the ability to resist the progression of chronic periodontitis.<\/jats:p>","DOI":"10.1902\/jop.1984.55.3.155","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T11:29:41Z","timestamp":1332329381000},"page":"155-158","source":"Crossref","is-referenced-by-count":22,"title":["Human Lymphocyte Antigen Haplotype and Resistance to Periodontitis"],"prefix":"10.1002","volume":"55","author":[{"given":"David","family":"Goteiner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J.","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1984,3]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1984.55.3.155","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:54:37Z","timestamp":1760882077000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1984.55.3.155"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,3]]}},"alternative-id":["10.1902\/jop.1984.55.3.155"],"URL":"https:\/\/doi.org\/10.1902\/jop.1984.55.3.155","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,3]]}}}