{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:02:02Z","timestamp":1762340522500,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1985,1,1]],"date-time":"1985-01-01T00:00:00Z","timestamp":473385600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:p><jats:sc>This study was undertaken<\/jats:sc> to determine the ability of inflamed and normal gingival tissues to synthesize Prostaglandins (PGs) from the precursor arachidonic acid. Thirteen samples of inflamed human gingival tissue and six samples of normal human gingival tissue were studied. The inflammation was characterized histologically. After incubation of the tissue with [<jats:sup>14<\/jats:sup>C]arachidonate, PG metabolites were separated by thin\u2010layer chromatography and identified by comparison with co\u2010chromatographed standards. Inflamed gingival tissue synthesized significantly larger amounts, compared to normal tissue, of 6\u2010keto\u2010PGF<jats:sub>1\u03b1<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.05), thromboxane B<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.01), PGD<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.05), and PGA<jats:sub>2<\/jats:sub> (<jats:italic>P<\/jats:italic> &lt; 0.001). Some unidentified metabolites, possibly lipoxygenase products, were detected in significantly (<jats:italic>P<\/jats:italic> &lt; 0.001) larger amounts in inflamed than in normal tissue.<\/jats:p>","DOI":"10.1902\/jop.1985.56.1.44","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T11:23:07Z","timestamp":1332328987000},"page":"44-47","source":"Crossref","is-referenced-by-count":31,"title":["Biosynthesis of Prostaglandins in Gingiva of Patients with Chronic Periodontitis"],"prefix":"10.1002","volume":"56","author":[{"given":"Carlos F.","family":"Mendieta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles M.","family":"Reeve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Carlos","family":"Romero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1985,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1985.56.1.44","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1985.56.1.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:17:56Z","timestamp":1760865476000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1985.56.1.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1902\/jop.1985.56.1.44"],"URL":"https:\/\/doi.org\/10.1902\/jop.1985.56.1.44","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}