{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T16:16:28Z","timestamp":1791476188120,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"11S","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1985,11]]},"abstract":"<jats:p><jats:sc><jats:italic>In vitro<\/jats:italic> susceptibilities of 369 to 966 bacterial<\/jats:sc> isolates from periodontal lesions to eight antibiotics were determined by agar dilution technique as a means of determining which antimicrobial agents were inhibitory for bacteria frequently associated with destructive periodontal diseases. Although most bacteria were relatively susceptible to the penicillins, greater activity was generally noted with amoxicillin than with either penicillin or ampicillin with the exception of <jats:italic>Selenomonas sputigena<\/jats:italic> and <jats:italic>Peptostreptococcus<\/jats:italic>. Antibacterial activities obtained with minocycline were significantly higher than with tetracycline for <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> and <jats:italic>Streptococcus<\/jats:italic> but comparable for most other taxa. Clindamycin and metronidazole both demonstrated excellent activity against the anaerobic Gram\u2010negative rods but were less effective against some of the capnophilic and facultative organisms. <jats:italic>Eikenella corrodens<\/jats:italic> was exceptionally resistant to both of these drugs; and <jats:italic>A. actinomycetemcomitans<\/jats:italic> was generally resistant to Clindamycin but relatively susceptible to metronidazole. Erythromycin was considerably less active than the other antibiotics against the majority of the periodontal bacteria. No single antibiotic, at concentrations equivalent to those achieved in body fluids, was uniformly effective in inhibiting all bacteria currently implicated or suspected as etiologic agents of periodontal diseases.<\/jats:p>","DOI":"10.1902\/jop.1985.56.11s.67","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T11:10:41Z","timestamp":1332328241000},"page":"67-74","source":"Crossref","is-referenced-by-count":66,"title":["Antibiotic Susceptibilities of Periodontal Bacteria: <i>In Vitro<\/i> Susceptibilities to Eight Antimicrobial Agents"],"prefix":"10.1002","volume":"56","author":[{"given":"Clay B.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet D.","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy Z.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Gordon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1985,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1985.56.11s.67","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1985.56.11s.67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:35:46Z","timestamp":1760873746000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1985.56.11s.67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,11]]},"references-count":0,"journal-issue":{"issue":"11S","published-print":{"date-parts":[[1985,11]]}},"alternative-id":["10.1902\/jop.1985.56.11s.67"],"URL":"https:\/\/doi.org\/10.1902\/jop.1985.56.11s.67","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,11]]}}}