{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:29:43Z","timestamp":1787023783339,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1987,9,1]],"date-time":"1987-09-01T00:00:00Z","timestamp":557452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1987,9]]},"abstract":"<jats:p>\n                    <jats:sc>Several studies have indicated that<\/jats:sc>\n                    the combination of metronidazole and spiramycin is synergistic against anaerobic bacteria and may be effective against oral infections. The present study sought to determine the efficacy and safety of a commercial preparation of these two antibiotics (Rodogyl) when used adjunctively in the treatment of advanced periodontal disease. In a double\u2010blind parallel randomized trial, 56 patients (mean age = 44 years) with advanced periodontitis (50 of whom completed the study) were assigned to either the Rodogyl or placebo group. Both groups were thoroughly scaled and root planed for approximately 6 hours, with one group receiving Rodogyl for 2 weeks and the other a placebo. No other therapy was received during the study period.\n                  <\/jats:p>\n                  <jats:p>Two sites in each patient with probing depths of at least 7 mm were selected for study. Plaque level (PlI), gingival inflammation (GI), probing depth (PD), and attachment level (AL) were measured at baseline, 14 days, 1 month, and then at monthly intervals up to 6 months. Subgingival bacteria were monitored with dark\u2010field microscopy. The development of resistant bacteria, as well as side effects to the medications, was also monitored.<\/jats:p>\n                  <jats:p>\n                    The Rodogyl group exhibited a greater gain in AL (0.67 mm) from the 2\u2010month interval until the end of the study. Although this difference was statistically significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05), it was not necessarily of biologic significance. There was a significantly greater decline in the proportion of spirochetes in the Rodogyl group at the 14\u2010day interval, and this difference remained significant (\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0.05) at all study intervals. No difference in the proportion of motile organisms was observed. At the 6\u2010month interval, there were no significant differences in resistant bacteria. Diarrhea was recorded in 8% of the subjects in the Rodogyl Group.\n                  <\/jats:p>\n                  <jats:p>The adjunctive use of Rodogyl in the therapy of advanced periodontitis resulted in a significant increase in attachment level as well as a significant decrease in the proportion of spirochetes, and both of these changes were sustained until the end of the study.<\/jats:p>","DOI":"10.1902\/jop.1987.58.9.594","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T09:56:19Z","timestamp":1332323779000},"page":"594-601","source":"Crossref","is-referenced-by-count":21,"title":["The Role of Adjunctive Rodogyl Therapy in the Treatment of Advanced Periodontal Disease"],"prefix":"10.1002","volume":"58","author":[{"given":"Trevor Chin","family":"Quee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.C.S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lautar\u2010Lemay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.\u2010J.","family":"Bergeron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bourgouin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Stamm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1987,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1987.58.9.594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:57:11Z","timestamp":1760875031000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1987.58.9.594"}},"subtitle":["A Longitudinal Clinical and Microbiologic Study"],"short-title":[],"issued":{"date-parts":[[1987,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1987,9]]}},"alternative-id":["10.1902\/jop.1987.58.9.594"],"URL":"https:\/\/doi.org\/10.1902\/jop.1987.58.9.594","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,9]]}}}