{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:20:43Z","timestamp":1762374043163,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1989,9,1]],"date-time":"1989-09-01T00:00:00Z","timestamp":620611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1989,9]]},"abstract":"<jats:p><jats:sc><jats:italic>actinobacillus actinomycetemcomitans<\/jats:italic> is thought<\/jats:sc> to play an important role in the pathogenesis of localized juvenile Periodontitis (LJP). Preliminary data suggested that the serotype distribution of <jats:italic>A. actinomycetemcomitans<\/jats:italic> in Korea and the United States differ. This study evaluated <jats:italic>A. actinomycetemcomitans<\/jats:italic> prevalence, serotype distribution, and leukotoxicity in Korean LJP patients by culture, enzyme\u2010linked immunosorbent assay, indirect immunofluorescence, and lactate dehydrogenase release from polymorphonuclear leukocytes exposed to <jats:italic>A. actinomycetemcomitans. A. actinomycetemcomitans<\/jats:italic> occurred in 75% of LJP lesions and 6% of normal sites with approximately equal distribution of serotype a, b, and c. Single serotypes were isolated from nine patients while three patients harbored two serotypes either in the same or different disease sites. <jats:italic>A. actinomycetemcomitans<\/jats:italic> leukotoxicity occurred in 22% isolates with a 69% prevalence. Individual sites harbored both leukotoxic and non\u2010leukotoxic strains with no serotype association. The distribution of serotypes and leukotoxic strains of <jats:italic>A. actinomycetemcomitans<\/jats:italic> in Korean LJP patients differed from those reported in the United States. This suggests that serotype b may not be more important in the pathogenesis of LJP. (<jats:italic>J Periodontol<\/jats:italic> 1989:60:506\u2013511.)<\/jats:p>","DOI":"10.1902\/jop.1989.60.9.506","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T08:07:20Z","timestamp":1332317240000},"page":"506-511","source":"Crossref","is-referenced-by-count":53,"title":["<i>Actinobacillus actinomycetemcomitans<\/i> Serotypes and Leukotoxicity in Korean Localized Juvenile Periodontitis"],"prefix":"10.1002","volume":"60","author":[{"given":"Hyun\u2010Ju","family":"Chung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chong\u2010Pyoung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong\u2010Heui","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Nisengard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1989.60.9.506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1989.60.9.506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:29:22Z","timestamp":1760873362000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1989.60.9.506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1989,9]]}},"alternative-id":["10.1902\/jop.1989.60.9.506"],"URL":"https:\/\/doi.org\/10.1902\/jop.1989.60.9.506","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1989,9]]}}}