{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:36:58Z","timestamp":1792118218488,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1990,11,1]],"date-time":"1990-11-01T00:00:00Z","timestamp":657417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1990,11]]},"abstract":"<jats:p>R<jats:sc>ecent interest in the local delivery<\/jats:sc> of antimicrobial and anti\u2010inflammatory agents has stimulated interest in the efficacy of various treatment regimens. Chlorhexidine gluconate (CHX) delivered daily by home\u2010applied marginal irrigation as a 0.04% solution in combination with a single professional irrigation of 0.12% CHX was tested over a 3month period. Sixty periodontal maintenance patients each having at least 2 pockets \u2265 4 mm probing depth, and bleeding on probing were assigned to either Group 1: one professional subgingival 0.12% CHX (Peridex) irrigation (Perio Pik) followed by adjunctive daily home marginal 0.04% CHX irrigation (Pik Pocket); Group 2: one professional subgingival 0.12% CHX irrigation followed by adjunctive daily home marginal water irrigation; Group 3: one professional subgingival water irrigation followed by adjunctive daily home marginal water irrigation; or Group 4: control. At baseline and 3 month visits, subgingival plaque samples were taken from 2 sites per patient. Cultural microbiological analysis was performed using non\u2010selective and selective media. Plaque Index, Gingival Index, pocket probing depths, and gingival recession were assessed. Scaling and root planing (supportive periodontal treatment) was provided for each patient followed by subgingival irrigation as outlined above. At 3 months the Gingival Index and pocket probing depths were both significantly reduced (<jats:italic>P<\/jats:italic> &lt;.05) in all irrigation groups compared to baseline. There were no significant changes in clinical parameters in the control group from baseline to 3 months. In Group 1 the GI was significantly reduced (<jats:italic>P<\/jats:italic> &lt;.05) compared to Group 4 at 3 months. <jats:italic>W. recta<\/jats:italic> and black\u2010pigmented <jats:italic>Bacteroides<\/jats:italic> sp were significantly reduced in Group 1 at 3 months compared to baseline. The findings suggest that it is possible to achieve beneficial clinical and microbiological effects from adjunctive professional 0.12% CHX and home 0.04% CHX subgingival irrigations in periodontal maintenance patients receiving supportive periodontal treatment. <jats:italic>J Periodontol 1990; 61:663\u2013669<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1990.61.11.663","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T06:16:33Z","timestamp":1332310593000},"page":"663-669","source":"Crossref","is-referenced-by-count":50,"title":["Clinical and Microbiological Effects of Subgingival and Gingival Marginal Irrigation With Chlorhexidine Gluconate"],"prefix":"10.1002","volume":"61","author":[{"given":"David L.","family":"Jolkovsky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Y.","family":"Waki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Otomo\u2010Corgel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles","family":"Madison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F.","family":"Flemmig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushma","family":"Nachnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessam","family":"Nowzari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1990.61.11.663","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T14:05:41Z","timestamp":1760882741000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1990.61.11.663"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1990,11]]}},"alternative-id":["10.1902\/jop.1990.61.11.663"],"URL":"https:\/\/doi.org\/10.1902\/jop.1990.61.11.663","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,11]]}}}