{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:32:40Z","timestamp":1793413960834,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1990,4,1]],"date-time":"1990-04-01T00:00:00Z","timestamp":638928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1990,4]]},"abstract":"<jats:p>T<jats:sc>he in vitro susceptibility<\/jats:sc> of 55 strains of subgingival plaque bacteria to minocycline was determined. A concentration of 1 \u03bcg\/ml minocycline was found to inhibit 85% of the strains tested and the MIC ranged from 0.03 to 32 <jats:italic>\u03bc<\/jats:italic>g\/ml. For 71% of the strains tested the MBC was at least 4 times greater than the corresponding MIC, suggesting a bacteriostatic activity for minocycline. A concentration of 20 mg\/ml of magnesium ions was capable of neutralizing 8 <jats:italic>\u03bc<\/jats:italic>g\/ml of minocycline and was used to eliminate \u201ccarryover\u201d effects inherent in the experimental procedure. After 6 to 7 weeks exposure to sub\u2010lethal concentrations of minocycline there was no appreciable increase in the MICs of most organisms with the exception of <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> NCTC 10981 and Campylobacter concisus NCTC 11485. Short term (6 hour) exposure of bacteria to minocycline (8 <jats:italic>\u03bc<\/jats:italic>g\/ml) markedly reduced the viability of a number of periodontopathogens but had little effect on the viability of <jats:italic>Veillonello parvula<\/jats:italic> NCTC 11456 and <jats:italic>Fusobacterium nucleatum<\/jats:italic> NCTC 11326. These in vitro investigations have demonstrated that minocycline is capable of inhibiting most of the periodontitis\u2010associated bacteria tested and can kill some of these bacteria after a comparatively short exposure time. However, some of the organisms tested exhibited a low susceptibility to minocycline and others became less susceptible following exposure to low concentrations of the antibiotic for several weeks. <jats:italic>J Periodontol 1990;61:228\u2010233.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1990.61.4.228","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T06:54:05Z","timestamp":1332312845000},"page":"228-233","source":"Crossref","is-referenced-by-count":45,"title":["Susceptibility and Resistance of Plaque Bacteria to Minocycline"],"prefix":"10.1002","volume":"61","author":[{"given":"B.C.","family":"O'Connor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. N.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1990.61.4.228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:16:12Z","timestamp":1760872572000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1990.61.4.228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1990,4]]}},"alternative-id":["10.1902\/jop.1990.61.4.228"],"URL":"https:\/\/doi.org\/10.1902\/jop.1990.61.4.228","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,4]]}}}