{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:16:50Z","timestamp":1790381810218,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>I<jats:sc>nterleukin<\/jats:sc>\u2010 1\u03b2 (IL\u20101\u03b2) <jats:sc>is the predominant form<\/jats:sc> of IL\u20101 produced by macrophages. IL\u20101\u03b2 possesses numerous and diverse biological activities. Several of these activities, including fibroblast proliferation, potentiation of the immune response, and stimulation of bone resorption may be of relevance to the pathogenesis of periodontal disease. This study was designed to examine the presence of IL\u20101\u03b2 in human periodontal tissue. An antiserum directed against the N\u2010terminal segment (117\u2010131) of human IL\u20101\u03b2 was used to detect IL\u20101\u03b2 using immunofluorescent staining techniques. IL\u20101\u03b2 positive staining cells were observed in both normal and diseased tissue and were limited to the lamina propria. Brightly staining cells were increased by almost 3\u2010fold in periodontally diseased tissue when compared to normal tissue. Low intensity staining cells were equally distributed in the normal and diseased specimens. We propose that IL\u20101\u03b2 and IL\u20101\u03b2 produced by cells in periodontal tissues may be related to the pathological processes associated with periodontal disease. <jats:italic>J Periodontol 1991;62:36\u201343<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1991.62.1.36","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T04:51:04Z","timestamp":1332305464000},"page":"36-43","source":"Crossref","is-referenced-by-count":78,"title":["Localization of Interleukin\u2010l\u03b2 in Human Periodontal Tissue"],"prefix":"10.1002","volume":"62","author":[{"given":"J.J.","family":"Jandinski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Stashenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.S.","family":"Feder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.C.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.J.","family":"Peros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Rynar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.J.","family":"Deasy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1991,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1991.62.1.36","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:12:17Z","timestamp":1760875937000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1991.62.1.36"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1902\/jop.1991.62.1.36"],"URL":"https:\/\/doi.org\/10.1902\/jop.1991.62.1.36","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}