{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:30:19Z","timestamp":1787023819446,"version":"build-2736575974"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>\n                    W\n                    <jats:sc>e report on the microbiological and clinical effects<\/jats:sc>\n                    of mechanical debridement in combination with metronidazole plus amoxicillin therapy in 118 patients with\n                    <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic>\n                    \u2010associated periodontitis. Patients were categorized into 3 groups: 28 had localized periodontitis; 50 had generalized periodontitis, and 40 had refractory periodontitis. After initial treatment and metronidazole plus amoxicillin therapy 114 of 118 (96.6%) patients had no detectable\n                    <jats:italic>A. actinomycetemcomitans.<\/jats:italic>\n                    Significant reduction in pocket probing depth and gain of clinical attachment were achieved in almost all patients. Four patients were still positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    after therapy. Metronidazole resistance (MIC &gt; 25 \u03bcg\/ml) was observed in 2 of 4 strains from these patients. Patients still positive for\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    or\n                    <jats:italic>Porphyromonas gingivalis<\/jats:italic>\n                    showed a significant higher bleeding tendency after therapy. It was concluded that mechanical periodontal treatment in combination with the metronidazole plus amoxicillin therapy is effective for subgingival suppression of\n                    <jats:italic>A. actinomycetemcomitans<\/jats:italic>\n                    in patients with severe periodontitis.\n                    <jats:italic>J Periodontol 1992;63:52\u201357.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/jop.1992.63.1.52","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T02:08:22Z","timestamp":1332295702000},"page":"52-57","source":"Crossref","is-referenced-by-count":183,"title":["Microbiological and Clinical Results of Metronidazole Plus Amoxicillin Therapy in\n                    <i>Actinobacillus actinomycetemcomitans<\/i>\n                    \u2010Associated Periodontitis"],"prefix":"10.1002","volume":"63","author":[{"given":"Arie J.","family":"van Winkelhoff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolien J.","family":"Tijhof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"de Graaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1992,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1992.63.1.52","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:24:34Z","timestamp":1760873074000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1992.63.1.52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1902\/jop.1992.63.1.52"],"URL":"https:\/\/doi.org\/10.1902\/jop.1992.63.1.52","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}