{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:01:54Z","timestamp":1762340514657,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1992,2,1]],"date-time":"1992-02-01T00:00:00Z","timestamp":696902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:p>S<jats:sc>everal forms of periodontal disease are considered<\/jats:sc> to be infectious diseases with associated specific bacteria. This study examined the humoral antibody levels as assayed by ELISA to <jats:italic>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis<\/jats:italic>, and <jats:italic>Prevotella intermedia<\/jats:italic> in adult Periodontitis (AP), localized juvenile Periodontitis (LJP), rapidly progressive Periodontitis (RPP), and in periodontally healthy subjects (HS). Sixty\u2010two of the 64 (96.9%) patients had significantly elevated antibody levels to at least one of the three organisms. Elevated levels of antibodies to <jats:italic>P. gingivalis<\/jats:italic> occurred in 82.8% of the RPP, LJP, and AP patients with all 3 disease groups showing greater responses than HS controls. Antibodies to <jats:italic>A. actinomycetemcomitans<\/jats:italic> were found in 59.4% of the RPP, LJP, and AP patients and were significantly higher in both LJP and RPP patients. Only 21.9% of the RPP, LJP, and AP patients showed elevated levels to <jats:italic>P. intermedia<\/jats:italic> with only significantly higher levels in the RPP and LJP groups. Antibodies to <jats:italic>A. actinomycetemcomitans<\/jats:italic> and <jats:italic>P. intermedia<\/jats:italic> were rarely found alone (only 5.1% and 2.6% of the patients respectively) but were usually accompanied by <jats:italic>P. gingivalis<\/jats:italic>.\u2010These results suggest that one or more combinations of these 3 bacteria may play a role in the pathogenesis of these forms of periodontal disease. <jats:italic>J Periodontol 1992; 63:80\u201386<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1992.63.2.80","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T02:30:44Z","timestamp":1332297044000},"page":"80-86","source":"Crossref","is-referenced-by-count":13,"title":["Humoral Antibody Responses in Periodontal Disease"],"prefix":"10.1002","volume":"63","author":[{"given":"George\u2010Gregory K.","family":"Zafiropoulos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lavinia","family":"Flores\u2010de\u2010Jacoby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus\u2010Dieter","family":"Hungerer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell J.","family":"Nisengard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1992.63.2.80","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:46:44Z","timestamp":1760881604000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1992.63.2.80"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,2]]}},"alternative-id":["10.1902\/jop.1992.63.2.80"],"URL":"https:\/\/doi.org\/10.1902\/jop.1992.63.2.80","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1992,2]]}}}