{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:44:45Z","timestamp":1760888685406,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[1992,3,1]],"date-time":"1992-03-01T00:00:00Z","timestamp":699408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1992,3]]},"abstract":"<jats:p>A<jats:sc>uto\u2010antibody to collagen<\/jats:sc>, previously detected in periodontal disease, may represent either a response to local tissue damage or be the manifestation of a disturbance of the host immune response induced by the periodontal flora and its products. In an effort to distinguish between these two hypotheses, this study was undertaken to determine circulating IgG auto\u2010antibody levels in 41 periodontal\u2010disease patients against 12 self\u2010antigens (salmon DS\u2010DNA, calf SS\u2010DNA, human and bovine thyroglobulin, rabbit proteoglycan, horse myoglobin, bovine myosin, actin, fetuin, human transferrin, cytochrome C, and human Type I collagen) and compare them to those in 21 periodontal disease\u2010free subjects. None of the detected IgG auto\u2010antibody levels were significantly different between periodontal disease and control sera (Mann\u2010Whitney U\u2010test, <jats:italic>P<\/jats:italic> &gt;0.05) except for human Type I collagen (<jats:italic>P<\/jats:italic> &lt;0.05). Fifty\u2010six percent of patients and 38% of controls were \u201cbroad responders;\u201d i.e., 50% or more of the auto\u2010antibody levels were higher than the median values of the control group; however, these values were not significantly different using the chi\u2010square test. It was concluded that the destruction of connective tissue components is the primary driving force in the induction of the enhanced auto\u2010antibody response found in periodontal disease. This response is apparently secondary to the primary bacterial infection which remains the major etiologic event. <jats:italic>J Periodontol 1992;63:194\u2013199<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1992.63.3.194","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T03:00:49Z","timestamp":1332298849000},"page":"194-199","source":"Crossref","is-referenced-by-count":10,"title":["Immunity to Self\u2010Antigens in Periodontal Disease"],"prefix":"10.1002","volume":"63","author":[{"given":"O.","family":"Anusahathien","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.J.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.E.","family":"Dolby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,3]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1992.63.3.194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:58:10Z","timestamp":1760871490000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1992.63.3.194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,3]]}},"alternative-id":["10.1902\/jop.1992.63.3.194"],"URL":"https:\/\/doi.org\/10.1902\/jop.1992.63.3.194","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1992,3]]}}}