{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:59:21Z","timestamp":1762865961348,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>G<jats:sc>ingival crevicular fluid<\/jats:sc> (GGF) was collected from the deepest probing site of each tooth of 10 chronic periodontitis patients prior to treatment, after scaling and hygiene treatment, and after periodontal surgery. Surgery was carried out at sites which had persistent probing depths in excess of 5 mm. The patients were given a full periodontal examination, including measurements of probing depth, gingival index, bleeding index, and plaque index before each GCF collection. Cathepsin B\/L\u2010, elastase\u2010, tryptase\u2010, trypsin\u2010, and dipeptidyl peptidase IV\u2010like activities in the GCF samples were determined by fluorimetric assay with peptidyl derivatives of 7\u2010amino\u20104\u2010trifluoromethyl coumarin. There were reductions in all clinical parameters and all protease activities after scaling and hygiene treatment and further reductions after periodontal surgery. Decreases were recorded for both total enzyme activities and concentrations. The reductions were statistically significant in inter\u2010patient comparisons using mean patient values and also in most intra\u2010patient comparisons using site data from individual patients. GCF protease levels appear to reflect the clinical status of periodontal lesions and may prove to be of value in monitoring disease activity. <jats:italic>J Periodontol 1992; 63:412\u2013417<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1992.63.5.412","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T03:22:34Z","timestamp":1332300154000},"page":"412-417","source":"Crossref","is-referenced-by-count":36,"title":["Cathepsin B\/L\u2010, Elastase\u2010, Tryptase\u2010, Trypsin\u2010 and Dipeptidyl Peptidase IVLike Activities in Gingival Crevicular Fluid: A Comparison of Levels Before and After Periodontal Surgery in Chronic Periodontitis Patients"],"prefix":"10.1002","volume":"63","author":[{"given":"Barry M.","family":"Eley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen W.","family":"Cox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1992.63.5.412","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1992.63.5.412","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:42:00Z","timestamp":1760870520000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1992.63.5.412"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1902\/jop.1992.63.5.412"],"URL":"https:\/\/doi.org\/10.1902\/jop.1992.63.5.412","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}