{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:18:09Z","timestamp":1760919489841,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>E<jats:sc>xperimental gingivitis was induced<\/jats:sc> in 2 groups of 10 adult Wistar rats by feeding them a high sucrose diet for 30 days. Since cyclosporin has an immunosuppressive effect on the stimulation of T lymphocytes, the test group received 5 intraperitoneal injections of cyclosporin A from day 20 to 30 while the control group received no additional treatment. The gingival regions of the molars were studied in light and transmission electron microscopy. In both groups, a well\u2010differentiated wall of polymorphonuclear neutrophils (PMNs) was present between the dental plaque and the papillary epithelium and no bacterial invasion occurred despite the local absence of T lymphocytes in the test group. It can be concluded that T lymphocytes are not involved in the mechanism of bacterial invasion. <jats:italic>J Periodontol 1993; 64:24\u201328<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1993.64.1.24","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T20:34:24Z","timestamp":1332362064000},"page":"24-28","source":"Crossref","is-referenced-by-count":5,"title":["Short\u2010Term Effect of Cyclosporin Injections on Experimental Gingival Inflammation in the Rat"],"prefix":"10.1002","volume":"64","author":[{"given":"Joseph","family":"Hemmerle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Frank","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1993.64.1.24","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:42:10Z","timestamp":1760863330000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1993.64.1.24"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1902\/jop.1993.64.1.24"],"URL":"https:\/\/doi.org\/10.1902\/jop.1993.64.1.24","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}