{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:56:34Z","timestamp":1767909394989,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1993,5,1]],"date-time":"1993-05-01T00:00:00Z","timestamp":736214400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1993,5]]},"abstract":"<jats:p>T<jats:sc>he present study was designed<\/jats:sc> to determine whether a polymeric composite promotes new attachment in artificially\u2010induced bony defects in the dog model. HTR, hard tissue replacement, is a non\u2010resorbable calcium\u2010layered polymer of polymethyl\u2010methacrylate and hydroxyethyl\u2010methacrylate. It has been reported to be clinically non\u2010inflammatory, osteophilic, and osteoconductive. For the study, 4 beagle dogs, 4 to 6 years old with no periodontal disease were used. Mucoperiosteal flaps were raised including the 2nd, 3rd, and 4th maxillary premolars. Buccal Class II furcation defects were created on these premolars. Reference notches were placed in the roots at the level of the bony defects. Test quadrants were selected by the toss of a coin, and furcations were filled with the polymeric composite particles wetted with sterile saline. Following grafting, the flaps were approximated and sutured. The contralateral side, serving as control, was treated by flap debridement only. Sutures were removed 7 days after surgery. Dogs were sacrificed 4 months following surgery. Mesio\u2010distal histological sections were evaluated by descriptive histology. In addition, surface area determinations (in mm<jats:sup>2<\/jats:sup>) of the furcal tissues were carried out using the microscope attached to a digitizer and a computer. In 8 mesio\u2010distal serial sections cut 30 <jats:italic>\u03bc<\/jats:italic>m apart in both experimental and control teeth, surface area determinations relative to the furcations were made evaluating: 1) the total fill of the furcation; 2) the area filled with alveolar bone; 3) the area occupied by connective tissue; 4) the area occupied by new deposited cementum; and 5) the area filled by epithelium. These measurements were statistically evaluated using the paired <jats:italic>t<\/jats:italic>test and the Wilcoxon signed rank test (n = 4). The animal was used as the statistical unit for assessing statistical significance. Overall, histologic responses showed that composite particles were well tolerated by the animals and caused no aberrant tissue responses. In general, the particles were encapsulated by connective tissue. However, periodontal healing following the use of the polymeric composite graft resulted in no increase in connective tissue and\/or alveolar bone regeneration. The polymer has acted as a biocompatible filler without evidence of new attachment associated with its use. <jats:italic>J Periodontol 1993; 64:343\u2013348<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1993.64.5.343","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T21:18:54Z","timestamp":1332364734000},"page":"343-348","source":"Crossref","is-referenced-by-count":10,"title":["Histologic and Histometric Responses to Polymeric Composite Grafts"],"prefix":"10.1002","volume":"64","author":[{"given":"A.E.","family":"Plotzke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.E.","family":"Nasjleti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.C.","family":"Morrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.G.","family":"Caffesse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1993.64.5.343","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:19:26Z","timestamp":1760865566000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1993.64.5.343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1993,5]]}},"alternative-id":["10.1902\/jop.1993.64.5.343"],"URL":"https:\/\/doi.org\/10.1902\/jop.1993.64.5.343","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,5]]}}}