{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:32:19Z","timestamp":1768437139747,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[1993,7,1]],"date-time":"1993-07-01T00:00:00Z","timestamp":741484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:p>D<jats:sc>ata from cross\u2010sectional studies<\/jats:sc> suggest that periodontitis in HIV\u2010infected patients is a more destructive form of disease in contrast to the slowly progressing form of adult periodontitis in the general population. We studied prospectively over an 18\u2010month period 30 HIV infected, but asymptomatic, patients and compared the rate of periodontal attachment loss with that of a healthy control group (n = 10) matched for age and plaque index. Every 6 months, each subject was assessed for their clinical status by a physician and CD4<jats:sup>+<\/jats:sup> cell count determined. The proliferative response of peripheral blood lymphocytes was determined by in vitro cultures with PHA and Con A. The periodontal health status was assessed by scoring with plaque index (PI), gingival index (GI), and periodontal disease index (PDI). The control subjects were assessed for periodontal status only. Of the 30 HIV\u2010positive patients whose data were analyzed 14 received Zidovudine (AZT) while the remaining 16 did not. There was no correlation between any clinical parameter measured and periodontal status as determined by PI or GI. However, a significant difference in the change of periodontal disease index (PDI) was observed between the HIV\u2010infected and control groups (<jats:italic>P<\/jats:italic> = 0.005). We concluded that HIVinfected patients with pre\u2010existing Periodontitis tend to experience a greater rate of attachment loss over time compared with controls. <jats:italic>J Periodontol 1993; 64:651\u2013657<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1993.64.7.651","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T21:09:59Z","timestamp":1332364199000},"page":"651-657","source":"Crossref","is-referenced-by-count":62,"title":["Progression of Periodontal Disease in HIV Seropositive Patients"],"prefix":"10.1002","volume":"64","author":[{"given":"Stephen C. H.","family":"Yeung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graeme J.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doungkamol","family":"Sindhusake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,7]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1993.64.7.651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:03:24Z","timestamp":1760871804000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1993.64.7.651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":0,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1902\/jop.1993.64.7.651"],"URL":"https:\/\/doi.org\/10.1902\/jop.1993.64.7.651","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}