{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T11:02:03Z","timestamp":1762340523560,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"8S","license":[{"start":{"date-parts":[[1993,8,1]],"date-time":"1993-08-01T00:00:00Z","timestamp":744163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:p>P<jats:sc>rior to the<\/jats:sc> 1950<jats:sc>s, periodontitis was treated<\/jats:sc> mostly by tooth exfoliation or extraction, and that is still the predominant treatment for most of the world's populations today. Debridement of the root surface by scaling and root planing came into relatively common use in the first half of the present century and has become the central feature held in common by all currently\u2010used forms of periodontal therapy. Until the 1980s, the most commonly\u2010used treatment consisted of scaling and root planing, followed by resective surgery aimed at achieving zero pocket depth. During the 1980s, data were obtained demonstrating that the thoroughness of root debridement and subgingival infection control, not the presence or absence or periodontal pockets, is the major determinant of successful periodontal therapy, and non\u2010surgical therapy became a commonlyused treatment. Neither resective surgery nor non\u2010surgical therapy results in significant regeneration of periodontal attachment. With the realization that periodontitis is an infectious process, the use of antibiotics and other anti\u2010infective agents came into common use as adjuncts to other standard therapies. An understanding of the pathways by which the soft and calcified tissues of the periodontium are destroyed has led to the likelihood of widespread future use of the non\u2010steroidal, anti\u2010inflammatory family of drugs to suppress alveolar bone destruction by blocking prostaglandin production, and to the use of chemically\u2010modified tetracyclines that chelate divalent cations and thereby block tissue destruction by the metalloproteinases. Recent data clearly show that regeneration of the previously\u2010destroyed periodontal attachment tissues is biologically possible, and regeneration has become the goal of therapy for the 1990s. Use of osteoconductive and osteoinductive graft materials can, under favorable conditions, induce roughly 60% to 70% regeneration of bone lesion height or volume with concomitant improvement in the clinical conditions. Regeneration by grafting may be further enhanced by use of barrier membranes that exclude gingival fibroblasts and epithelium from the healing site. Still further enhancement seems to be possible by local application of various growth factors, although studies in this important area are now only in their infancy. The future of periodontal therapy is exceedingly bright. It seems likely that we may be able to achieve nearly complete regeneration of periodontal attachment at many, although not all, sites through the use of root debridement and anti\u2010infective and anti\u2010inflammatory drugs and agents that inhibit metalloproteinases to arrest progress of disease and resolve the inflammatory process, followed by the combined use of graft material, barrier membranes, and growth factors to induce regeneration of periodontal attachment tissues. <jats:italic>J Periodontol 1993; 64:744\u2013753.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1993.64.8s.744","type":"journal-article","created":{"date-parts":[[2012,3,21]],"date-time":"2012-03-21T21:41:42Z","timestamp":1332366102000},"page":"744-753","source":"Crossref","is-referenced-by-count":21,"title":["Periodontal Therapy: Prospects for the Future"],"prefix":"10.1002","volume":"64","author":[{"given":"Roy C.","family":"Page","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,8]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1993.64.8s.744","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T10:19:52Z","timestamp":1760869192000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1993.64.8s.744"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,8]]},"references-count":0,"journal-issue":{"issue":"8S","published-print":{"date-parts":[[1993,8]]}},"alternative-id":["10.1902\/jop.1993.64.8s.744"],"URL":"https:\/\/doi.org\/10.1902\/jop.1993.64.8s.744","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1993,8]]}}}