{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:14:15Z","timestamp":1792613655731,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[1994,11,1]],"date-time":"1994-11-01T00:00:00Z","timestamp":783648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1994,11]]},"abstract":"<jats:p>T<jats:sc>he clinical efficacy of Minocycline<\/jats:sc> in a subgingival local delivery system was evaluated alone (M) or as an adjunct to scaling and root planing (M+SRP), in comparison to scaling and root planing (SRP) or to no subgingival treatment (NoTx) in adult periodontitis. Fifty\u2010one adult patients with \u22657 mm periodontal pockets demonstrating the presence by culture of <jats:italic>Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi)<\/jats:italic>, or <jats:italic>Actinobacillus actinomycetemcomitans (Aa)<\/jats:italic> were randomized into one of the above 4 treatment groups. All sites \u22655 mm in the most diseased quadrant in each patient received the therapy. Other quadrants were not treated. All patients received standardized oral hygiene instructions at the beginning of the study. At 0, 1, 3, and 6 months following therapy the 7 mm experimental sites were evaluated for selected periodontal pathogens by DNA probe analysis. At these same time points, the plaque index, gingival index, and bleeding on probing were evaluated as well as probing depth and relative clinical attachment level which were assessed by means of an automated probe. Probing depth reduction with M+SRP was significantly greater than all other groups at one month and significantly greater than NoTx and SRP at 3 months. There were no differences in probing depth reduction among groups at 6 months. At 6 months the gain in clinical attachment level was significantly greater for SRP than for either the NoTx or M groups. The prevalence of <jats:italic>Pg<\/jats:italic> decreased significantly in the M and M+SRP groups at one month. The prevalence of <jats:italic>Pi<\/jats:italic> decreased significantly from baseline at one month in the M group. No other significant microbiological differences between groups were noted. In terms of clinical probing depth, subgingival minocycline as an adjunct to SRP may produce significant clinical benefits over SRP alone in patients with adult periodontitis. This benefit may be related to a decrease in prevalence of <jats:italic>Pg. J Periodontol 1994; 65:1058\u20131066<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1994.65.11.1058","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T23:39:43Z","timestamp":1332286783000},"page":"1058-1066","source":"Crossref","is-referenced-by-count":55,"title":["Clinical and Microbiological Effects of Controlled\u2010Release Locally Delivered Minocycline in Periodontitis"],"prefix":"10.1002","volume":"65","author":[{"given":"Archie A.","family":"Jones","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Kornman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewey A.","family":"Newbold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Manwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1994,11]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1994.65.11.1058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:28:15Z","timestamp":1760876895000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1994.65.11.1058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,11]]},"references-count":0,"journal-issue":{"issue":"11","published-print":{"date-parts":[[1994,11]]}},"alternative-id":["10.1902\/jop.1994.65.11.1058"],"URL":"https:\/\/doi.org\/10.1902\/jop.1994.65.11.1058","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,11]]}}}