{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:24:39Z","timestamp":1761863079688,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>P<jats:sc>latelets<\/jats:sc> (PL) <jats:sc>may be involved<\/jats:sc> in the inflammatory process through the release of a variety of factors which could contribute to gingival tissue injury. Thus, conditions which result in the localized discharge of PL constituents could lead to amplification of the inflammatory process at these sites. The purpose of this study was to determine if there was evidence of PL activation in gingival crevicular fluid and whether the degree of gingival inflammation, as measured by the gingival index (GI), was associated with the degree of platelet activation. This was monitored by assaying for betathromboglobulin (<jats:italic>\u03b2<\/jats:italic>\u2010TG), a platelet specific protein released from alpha granules of PL when activated. One uL samples of the fluids were obtained from human subjects from gingival sites with various GI scores. Fluid samples were also obtained at probeinduced bleeding gingival crevicular sites. <jats:italic>\u03b2<\/jats:italic>\u2010TG levels in the various fluids obtained from the crevice were determined by radioimmunoassay (RIA). The RIA data indicated that detectable <jats:italic>\u03b2<\/jats:italic>\u2010TG levels were observed in all samples, the means ranging from 5.5 ng\/ml to 45.2 ng\/ml. Additionally, a positive association between the GI scores of 0 and 1 and the <jats:italic>\u03b2<\/jats:italic>\u2010TG levels where observed. For GI scores of 2 and above the <jats:italic>\u03b2<\/jats:italic>\u2010TG concentrations appeared to approach a maximum value. These findings provide evidence for PL activation and suggest a relationship with gingival inflammation. <jats:italic>J Periodontol 1995;66:860\u2013863<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1995.66.10.860","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T22:14:23Z","timestamp":1332281663000},"page":"860-863","source":"Crossref","is-referenced-by-count":10,"title":["Platelet Association With Gingival Tissue Inflammation"],"prefix":"10.1002","volume":"66","author":[{"given":"Arnold D.","family":"Steinberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario E.A.F.","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeannette","family":"Lipowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy C.","family":"Lebreton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.10.860","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:18:43Z","timestamp":1760872723000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1995.66.10.860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1902\/jop.1995.66.10.860"],"URL":"https:\/\/doi.org\/10.1902\/jop.1995.66.10.860","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}