{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:53:25Z","timestamp":1762271605983,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1995,10,1]],"date-time":"1995-10-01T00:00:00Z","timestamp":812505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1995,10]]},"abstract":"<jats:p>A<jats:sc>n increased incidence of antibiotic\u2010resistant<\/jats:sc> bacteria and yeast overgrowth has been reported following various periodontal treatments. The objective of this study was to detect possible overgrowth of opportunistic bacteria and fungi as well as changes in normal microbiota after application of a biodegradable delivery system containing 5% sanguinarium (ABDS\u2010S) to one quadrant in a split\u2010mouth study. An oral hygiene quadrant served as a control. The ABDS\u2010S treated and control periodontal sites as well as the saliva of 17 subjects were sampled prior to treatment, immediately after ABDS\u2010S removal at 7 days, and again at 30 and 60 days. At Day 7 sanguinariumresistant bacteria increased in both control and ABDS\u2010S periodontal sites as well as in the saliva. Enteric Gram\u2010negative bacilli in both control and ABDS\u2010S periodontal sites were 2.2 to 3.4 log colony forming units higher at Day 7 compared to baseline. This overgrowth was transient in that levels became undetectable at Days 30 and 60. No such overgrowth was observed for <jats:italic>C. albicans<\/jats:italic> or other fungi, or for <jats:italic>S. aureus<\/jats:italic> or other staphylococci in any periodontal sites. Levels of <jats:italic>Actinomyces<\/jats:italic> increased at Days 30 and 60 in both control and ABDS\u2010S sites as well as saliva. These changes strongly suggest that a 7 day ABDS\u2010S treatment in one quadrant of the mouth led to significant microbiota changes in the treated and control quadrants as well as in the saliva. Future microbial studies involving antimicrobials delivered by local delivery systems must consider the crossover effects of treatment inherent in the split\u2010mouth design. <jats:italic>J Periodontol 1995;66:870\u2013877<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1995.66.10.870","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T22:14:23Z","timestamp":1332281663000},"page":"870-877","source":"Crossref","is-referenced-by-count":19,"title":["Whole Mouth Microbiota Effects Following Subgingival Delivery of Sanguinarium"],"prefix":"10.1002","volume":"66","author":[{"given":"Kenneth C.","family":"Godowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elyse D.","family":"Wolff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dennis M.","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carol J.","family":"Housley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan M.","family":"Polson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan P.","family":"Duke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norman H.","family":"Staller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. Lee","family":"Southard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.10.870","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T11:18:41Z","timestamp":1760872721000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1995.66.10.870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1995,10]]}},"alternative-id":["10.1902\/jop.1995.66.10.870"],"URL":"https:\/\/doi.org\/10.1902\/jop.1995.66.10.870","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1995,10]]}}}