{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T04:16:26Z","timestamp":1790223386311,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[1995,2,1]],"date-time":"1995-02-01T00:00:00Z","timestamp":791596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1995,2]]},"abstract":"<jats:p>T<jats:sc>his study evaluated bone and cementum regeneration<\/jats:sc> following periodontal reconstructive surgery using recombinant human bone morphogenetic protein\u20102 (rhBMP2) in six beagle dogs. Surgically created mandibular supraalveolar premolar tooth defects in contralateral jaw quadrants were randomly assigned to receive rhBMP\u20102 or control vehicle. Clinical defect height was prepared to 5 mm. rhBMP\u20102 was applied with synthetic bioerodable particles and autologous blood using 20 \u03bcg rhBMP\u20102 per 100 \u03bcl implant volume. Flaps were advanced to submerge the teeth and sutured. The dogs were sacrificed 8 weeks postsurgery. Histometric recordings included defect height, height and area of alveolar bone regeneration, height of cementum regeneration, root resorption, and ankylosis. Group means, standard deviations, and <jats:italic>P<\/jats:italic> values are shown (Student <jats:italic>t<\/jats:italic> test; n = 6). Histometric defect height for rhBMP\u20102 and control defects was 3.7\u00b10.3 and 3.9\u00b10.4 mm, respectively (<jats:italic>P<\/jats:italic> = 0.446). Height of alveolar bone regeneration amounted to 3.5\u00b10.6 and 0.8\u00b10.6 mm for rhBMP\u20102 and control defects, respectively (<jats:italic>P<\/jats:italic> = 0.000). Corresponding values for bone area were 8.4\u00b14.5 and 0.4\u00b10.5 mm<jats:sup>2<\/jats:sup>, respectively (<jats:italic>P<\/jats:italic> = 0.006). Cementum regeneration was observed in all experimental defects (17\/17) and in 15 out of 17 controls, averaging 1.6\u00b10.6 and 0.4\u00b10.3 mm for rhBMP\u20102 and control defects, respectively (<jats:italic>P<\/jats:italic> = 0.005). Small amounts of root resorption were seen in rhBMP2 defects, whereas controls exhibited substantial resorption (0.2\u00b10.1 and 1.1\u00b10.3 mm, respectively; <jats:italic>P<\/jats:italic> = 0.001). When present, ankylosis was limited and localized in both rhBMP\u20102 and control defects, suggesting it was unrelated to the experimental variable. Our data suggest that wound conditioning with rhBMP\u20102 has a significant potential for stimulating periodontal regeneration. <jats:italic>J Periodontol 1995; 66:131\u2013138.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1995.66.2.131","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T20:59:54Z","timestamp":1332277194000},"page":"131-138","source":"Crossref","is-referenced-by-count":210,"title":["Periodontal Repair in Dogs: Recombinant Human Bone Morphogenetic Protein\u20102 Significantly Enhances Periodontal Regeneration"],"prefix":"10.1002","volume":"66","author":[{"given":"Thorarinn J.","family":"Sigurdsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohzoh","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Turek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Wozney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf M.E.","family":"Wikesj\u00f6","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1995,2]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.2.131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.2.131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:47:32Z","timestamp":1760863652000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1995.66.2.131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,2]]}},"alternative-id":["10.1902\/jop.1995.66.2.131"],"URL":"https:\/\/doi.org\/10.1902\/jop.1995.66.2.131","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,2]]}}}