{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:16:11Z","timestamp":1790648171289,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1995,9,1]],"date-time":"1995-09-01T00:00:00Z","timestamp":809913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1995,9]]},"abstract":"<jats:p>S<jats:sc>everal dentifrices that contain hydrogen peroxide<\/jats:sc> are currently being marketed. The increased use of bleaching agents containing (or generating) H2O2 prompted this review of the safety of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> when used in oral hygiene. Daily exposure to the low levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> present in dentifrices is much lower than that of bleaching agents that contain or produce high levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> for an extended period of time. Hydrogen peroxide has been used in dentistry alone or in combination with salts for over 70 years. Studies in which 3% H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> or less were used daily for up to 6 years showed occasional transitory irritant effects only in a small number of subjects with preexisting ulceration, or when high levels of salt solutions were concurrently administered. In contrast, bleaching agents that employ or generate high levels of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> or organic peroxides can produce' localized oral toxicity following sustained exposure if mishandled. Potential health concerns related to prolonged hydrogen peroxide use have been raised, based on animal studies. From a single study using the hamster cheek pouch model, 30% H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> was referred to as a cocarcinogen in the oral mucosa. This (and later) studies have shown that at 3% or less, no cocarcinogenic activity or adverse effects were observed in the hamster cheek pouch following lengthy exposure to H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub>. In patients, prolonged use of hydrogen peroxide decreased plaque and gingivitis indices. However, therapeutic delivery of H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> to prevent periodontal disease required mechanical access to subgingival pockets. Furthermore, wound healing following gingival surgery was enhanced due to the antimicrobial effects of topically administered hydrogen peroxide. For most subjects, beneficial effects were seen with H<jats:sub>2<\/jats:sub>O<jats:sub>2<\/jats:sub> levels above 1%. <jats:italic>J Periodontol 1995;66:786\u2013796<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1995.66.9.786","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T23:07:11Z","timestamp":1332284831000},"page":"786-796","source":"Crossref","is-referenced-by-count":125,"title":["Hydrogen Peroxide: A Review of Its Use in Dentistry"],"prefix":"10.1002","volume":"66","author":[{"given":"Milton V.","family":"Marshall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lewis P.","family":"Cancro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Fischman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1995,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.9.786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1995.66.9.786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:37:56Z","timestamp":1760866676000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1995.66.9.786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1902\/jop.1995.66.9.786"],"URL":"https:\/\/doi.org\/10.1902\/jop.1995.66.9.786","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}