{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T23:25:30Z","timestamp":1777332330981,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1996,8,1]],"date-time":"1996-08-01T00:00:00Z","timestamp":838857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1996,8]]},"abstract":"<jats:p>T<jats:sc>his study evaluated new bone formation<\/jats:sc> in human extraction sockets treated with demineralized freeze\u2010dried bone allografts (DFDBA) and cell occlusive membranes. Hard tissue biopsies of 7 sites in 6 patients were obtained 14 weeks to 13 months following extraction and grafting. Histologic analysis revealed that individual particles of DFDBA were discernible up to 13 months <jats:italic>in situ<\/jats:italic>. In all samples, all particles of DFDBA were well incorporated within new bone, which exhibited osteocyte\u2010containing lacunae. Distinct cement lines clearly demarcated the DFDBA particles from the surrounding, intimately\u2010apposed woven and lamellar bone. The marrow demonstrated a mild degree of fibrosis without signs of inflammatory reaction. There was also a notable lack of fibrous encapsulation of the allograft, and little osteoclasis was observed. Our findings demonstrate that commercially available DFDBA has the potential to function physically as a nidus for appositional new bone growth in alveolar sockets following tooth extraction. Further investigations of the biological activity of DFDBA <jats:italic>in situ<\/jats:italic> are warranted. <jats:italic>J Periodontol 1996;67:821\u2013825<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1996.67.8.821","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T20:53:13Z","timestamp":1332276793000},"page":"821-825","source":"Crossref","is-referenced-by-count":45,"title":["Histologic Evaluation of Human Extraction Sockets Treated With Demineralized Freeze\u2010Dried Bone Allograft (DFDBA) and Cell Occlusive Membrane"],"prefix":"10.1002","volume":"67","author":[{"given":"Federico","family":"Brugnami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter R.","family":"Then","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetada","family":"Moroi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cataldo W.","family":"Leone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,8]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1996.67.8.821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:03:07Z","timestamp":1760875387000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1996.67.8.821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1996,8]]}},"alternative-id":["10.1902\/jop.1996.67.8.821"],"URL":"https:\/\/doi.org\/10.1902\/jop.1996.67.8.821","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,8]]}}}