{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:17:12Z","timestamp":1790731032868,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[1997,4,1]],"date-time":"1997-04-01T00:00:00Z","timestamp":859852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>T<jats:sc>he purpose of this study<\/jats:sc> was to evaluate the safety and clinical efficacy of controlledrelease tetracycline\u2010containing fibers in patients with refractory periodontitis versus the preceding classical treatment. One hundred twenty\u2010one sites in 20 patients were followed from baseline to 6 months after fiber insertion. Each selected site was \u22655 mm deep and bled on probing. All 20 patients had at least one site \u22657 mm which bled on probing. Those pockets remained after intense and repeated conventional therapy (scaling and root planing and often surgery), often including the use of systemic antibiotics. This treatment period, the so\u2010called control period, preceded the experimental period by at least 3 years, when the fibers were placed. Both treatments (in control and test period) were performed in the Department of Periodontology at the University Hospital in Leuven. At the start of the experimental period, all pockets \u22655 mm were treated by the placement of fibers impregnated with 25% tetracycline. The fibers were removed after 10 days. Probing depth, clinical attachment level, gingival recession, and bleeding on probing were recorded at baseline, and at 1, 3, and 6 months following treatment. Analysis of data from all sites indicated that a significant decrease in probing depth and gain in attachment were present at all follow\u2010up visits. The mean probing depth reduction for sites \u22657 mm was 3.2 mm at month 6, with a gain in attachment of 2.7 mm, while this was \u22121.0 mm and \u22121.9 mm, respectively, during the preceding control period. The fraction of bleeding pockets was reduced from 77% to 27% and from 80% to 77% during the experimental and control periods, respectively. No significant adverse side\u2010effects were observed, except for a transient redness at fiber removal in 2 sites. Fiber insertion appeared to be time\u2010consuming even when the operator was familiarized with the procedure. The results of this study prove that tetracycline\u2010impregnated fibers can reduce probing depth significantly for a period of 6 months in patients not responding to thorough and repeated classical periodontal treatment. <jats:italic>J Periodontol 1997;68:353\u2013361<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1997.68.4.353","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T17:14:46Z","timestamp":1332263686000},"page":"353-361","source":"Crossref","is-referenced-by-count":65,"title":["The Use of Tetracycline\u2010Containing Controlled\u2010Release Fibers in the Treatment of Refractory Periodontitis"],"prefix":"10.1002","volume":"68","author":[{"given":"Betty N.A.","family":"Vandekerckhove","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"van Steenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,4]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.4.353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:54:17Z","timestamp":1760867657000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.4.353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1902\/jop.1997.68.4.353"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.4.353","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}