{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:36:43Z","timestamp":1780587403787,"version":"3.54.1"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[1997,5,1]],"date-time":"1997-05-01T00:00:00Z","timestamp":862444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,5]]},"abstract":"<jats:p>T<jats:sc>he aim of this investigation<\/jats:sc> was to evaluate the effect of smoking on the outcome of periodontal therapy. The study consisted of 54 patients who participated in a 4\u2010group parallel\u2010arm clinical trial on the efficacy of three locally delivered antimicrobial systems as adjuncts to scaling and root planing in the treatment of sites with persistent pocketing after a course of scaling and root planing. These groups included scaling and root planing either alone (S) (n = 3), or in conjunction with the application of 25% tetracycline fibers (S&amp;T) (n = 13), 2% minocycline gel (S&amp;Mi) (n = 14), or 25% metronidazole gel (S&amp;Me) (n = 14). In each patient four pockets &gt; 5 mm with bleeding on probing (BOP) and\/or suppuration were studied. The number of subjects who smoked was: 8 (61.5%) in the S&amp;T group, 8 (57.1%) in the S&amp;Mi group, 6 (42.9%) in the S&amp;Me group, and 6 (46.2%) in the S group. The probing depth, attachment level and other clinical parameters were assessed at baseline and 6 weeks after treatments. The clinical results of this comparative study have been previously reported. Regardless of the type of treatment, the change in the probing depth (\u0394PD) and attachment gain (\u0394AL) were greater in non\u2010smoker subjects than smoker subjects. \u0394PD was 1.14 mm versus 0.76 mm (<jats:italic>P<\/jats:italic> = 0.019), and \u0394AL was 0.52 mm versus 0.50 mm at (<jats:italic>P<\/jats:italic> = 0.845) for non\u2010smokers and smokers respectively. The analysis of variance using the general linear model (GLM) was used for \u0394PD and \u0394AL and took into account the variations in the treatments, number of smoker subjects per group, and baseline probing depth. There was a significant interaction between the \u201csmoking\u201d and the \u201cbaseline PD.\u201d Further analysis using linear regression indicated that, while there was a significant relationship between the baseline PD and the \u0394PD or \u0394AL among the non\u2010smokers, weak and insignificant relationship existed among the smoker subjects. Thus, smoking may have an important role in determining the prognosis of periodontal treatment, particularly in persistent and deep pockets. <jats:italic>J Periodontol 1997;68:467\u2013472.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1997.68.5.467","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T17:41:32Z","timestamp":1332265292000},"page":"467-472","source":"Crossref","is-referenced-by-count":73,"title":["The Effect of Smoking on Mechanical and Antimicrobial Periodontal Therapy"],"prefix":"10.1002","volume":"68","author":[{"given":"D.F.","family":"Kinane","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Radvar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,5]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.5.467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:39:01Z","timestamp":1760877541000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.5.467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1997,5]]}},"alternative-id":["10.1902\/jop.1997.68.5.467"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.5.467","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,5]]}}}