{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:22:52Z","timestamp":1760919772406,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1997,8,1]],"date-time":"1997-08-01T00:00:00Z","timestamp":870393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,8]]},"abstract":"<jats:p>R<jats:sc>ecent work has indicated<\/jats:sc> that <jats:italic>Bacteroides forsythus<\/jats:italic> and <jats:italic>Porphyromonas gingivalis<\/jats:italic> are significant local risk factors for periodontitis. Several reports find that both organisms are frequently associated with periodontitis lesions and often are present together. We have previously shown that early\u2010onset periodontitis patients seropositive for <jats:italic>P. gingivalis<\/jats:italic> have less attachment loss than seronegative patients. In this study, we determined serum IgG antibody concentrations reactive with <jats:italic>B. forsythus<\/jats:italic> in adult and early\u2010onset periodontitis patients using an ELISA and used <jats:italic>P. gingivalis<\/jats:italic> in the same populations as a positive control. The results for <jats:italic>P. gingivalis<\/jats:italic> were consistent with previous work and indicated that 47%, 36%, and 33% of adult, generalized earlyonset, and localized juvenile patients were seropositive, respectively. Mean serum IgG concentrations for the three groups were 5.36 \u03bcg\/ml, 5.65 \u03bcg\/ml, and 5.44 \u03bcg\/ml for adult, generalized early\u2010onset, and localized juvenile patients, respectively. In contrast, for <jats:italic>B. forsythus<\/jats:italic> only 11%, 14%, and 10% of adult, generalized early\u2010onset, and localized juvenile patients were seropositive, with mean serum IgG concentrations of 0.46 \u03bcg\/ml, 0.46 \u03bcg\/ml, and 0.47 \u03bcg\/ml, respectively. This suggests that <jats:italic>B. forsythus<\/jats:italic> is either poorly immunogenic or less invasive than <jats:italic>P. gingivalis<\/jats:italic>. If most patients fail to mount an immune response to <jats:italic>B. forsythus<\/jats:italic> and it is invasive, it may explain why this organism is a risk factor for disease. <jats:italic>J Periodontol 1997;68:734\u2013738<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1997.68.8.734","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T18:22:59Z","timestamp":1332267779000},"page":"734-738","source":"Crossref","is-referenced-by-count":23,"title":["A Comparison of IgG Antibody Reactive With <i>Bacteroides forsythus<\/i> and <i>Porphyromonas gingivalis<\/i> in Adult and Early\u2010Onset Periodontitis"],"prefix":"10.1002","volume":"68","author":[{"given":"Joseph V.","family":"Califano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Gunsolley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey A.","family":"Schenkein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Tew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,8]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.8.734","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:16:39Z","timestamp":1760865399000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.8.734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,8]]}},"alternative-id":["10.1902\/jop.1997.68.8.734"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.8.734","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}