{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T06:00:20Z","timestamp":1778133620988,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>H<jats:sc>igh titers of serum<\/jats:sc> IgG2 reactive with <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> are present in early\u2010onset periodontitis (EOP) patients and it appears that anti\u2010<jats:italic>A. actinomycetemcomitans<\/jats:italic> may be protective. Smoking is associated with increased periodontal disease severity in generalized early\u2010onset periodontitis (G\u2010EOP) patients, but is not associated with periodontal disease severity in patients with localized juvenile periodontitis (LJP). Furthermore, smoking is associated with reduced serum IgG2 levels in black patients with G\u2010EOP but not in those with LJP. Based on this selective effect of smoking, we hypothesized that smoking would be associated with a reduction of specific IgG2 reactive with <jats:italic>A. actinomycetemcomitans<\/jats:italic> in black G\u2010EOP patients but not black LJP patients. In addition, we examined IgG2 responses to carbohydrate antigens from non\u2010periodontal pathogens including <jats:italic>Haemophilus influenzae<\/jats:italic> b Oligosaccharide antigen (Hib) and the <jats:italic>Streptococcus pneumoniae<\/jats:italic> antigen phosphocholine (PC). Smoking status was assessed from serum cotinine levels, and IgG2 specific for <jats:italic>A. actinomycetemcomitans<\/jats:italic>, Hib, and PC was assessed by ELISA. Our study revealed that smoking was correlated with a dramatic reduction in serum IgG2 anti\u2010<jats:italic>A. actinomycetemcomitans<\/jats:italic> in G\u2010EOP smokers but not in LJP smokers. In contrast, anti\u2010Hib IgG2 and anti\u2010PC IgG2 were not affected in either G\u2010EOP or LJP patients. In short, these results indicate that smoking is associated with a reduction in serum IgG2 anti<jats:italic>A. actinomycetemcomitans<\/jats:italic> in black G\u2010EOP subjects, but IgG2 reactive with other antigens may not be reduced in G\u2010EOP smokers. <jats:italic>J Periodontol 1997;68:842\u2013850<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1997.68.9.842","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T18:50:16Z","timestamp":1332269416000},"page":"842-850","source":"Crossref","is-referenced-by-count":50,"title":["The Effect of Smoking on Serum IgG2 Reactive With <i>Actinobacillus actinomycetemcomitans<\/i> in Early\u2010Onset Periodontitis Patients"],"prefix":"10.1002","volume":"68","author":[{"given":"Srilatha D.","family":"Tangada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph V.","family":"Califano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keisuke","family":"Nakashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen M.","family":"Quinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji\u2010Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Gunsolley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harvey A.","family":"Schenkein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Tew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.9.842","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.9.842","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:05:46Z","timestamp":1760879146000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.9.842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1902\/jop.1997.68.9.842"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.9.842","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}