{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:39:53Z","timestamp":1760920793004,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>Th2 <jats:sc>type lymphocytes are characterized<\/jats:sc> by high expression of CD30 glycoprotein. Increased serum levels of CD30 and Th2 IL\u20104 producing T\u2010cells are found during AIDS progression. Since HIV\u2010positive patients are more susceptible to periodontal disease, quantitative analysis of positive cells for the CD30 receptor in chronic gingivitis of both HIV\u2010infected and non\u2010infected patients (NSG) would help to clarify the immunoregulation of HIV\u2010associated periodontal diseases. The purpose of this study was to evaluate CD30<jats:sup>+<\/jats:sup> lymphocytes in gingival biopsies from sites exhibiting chronic gingivitis on HIV\u2010positive patients (CG\u2010HIV) and NSG. A biotin\u2010streptavidin amplified system was used for identification of the CD30 receptor. The results demonstrated increased proportions of Th2 cells in CG\u2010HIV as compared to NSG. Additional studies are necessary to understand the importance of these cells to the biological activity or inactivity of the disease. <jats:italic>J Periodontol 1997;68:881\u2013883<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1997.68.9.881","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T18:50:16Z","timestamp":1332269416000},"page":"881-883","source":"Crossref","is-referenced-by-count":3,"title":["CD30<sup>+<\/sup> Lymphocytes in Chronic Gingivitis From HIV\u2010Positive Patients: A Pilot Study"],"prefix":"10.1002","volume":"68","author":[{"given":"Ricardo Santiago","family":"Gomez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Eduardo Alencar","family":"de Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Eust\u00e1quio","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ney Soares","family":"Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.9.881","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:05:45Z","timestamp":1760879145000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.9.881"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1902\/jop.1997.68.9.881"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.9.881","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}