{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:48:32Z","timestamp":1788187712789,"version":"build-2803163510"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1997,9,1]],"date-time":"1997-09-01T00:00:00Z","timestamp":873072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1997,9]]},"abstract":"<jats:p>T<jats:sc>he influence of chemical plaque control<\/jats:sc>, using topically applied 0.12% chlorhexidine, on the severity of cyclosporin A (CsA)\u2010induced gingival overgrowth (GO) was evaluated. Forty Holtzman rats were divided into four groups: 1) control; 2) cyclosporin A: a 10mg\/kg\/day subcutaneous dose of CsA; 3) chlorhexidine: 0.12% chlorhexidine (CHX) was applied to the buccal surface of the right mandibular molars; and 4) cyclosporin A\/chlorhexidine: a combination of the treatment described for cyclosporin A and chlorhexidine groups. The animals were fed a high sucrose diet during the experiment and were sacrificed after 14 and 21 days. The histometric analysis revealed a significant increase in buccal gingival area in the cyclosporin A group compared to other groups (<jats:italic>P<\/jats:italic> &lt; 0.01) after 21 days. The epithelium thickness of the buccal gingiva was significantly increased in the cyclosporin A group, compared to the control group (<jats:italic>P<\/jats:italic> &lt; 0.05). The cyclosporin A\/chlorhexidine group exhibited statistically significantly lower gingival overgrowth than the cyclosporin A group. These findings, if replicated in human studies, suggest that topically applied 0.12% chlorhexidine may be a valuable measure in the management of cyclosporin\u2010induced gingival overgrowth. <jats:italic>J Periodontol 1997;68:900\u2013904<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1997.68.9.900","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T18:50:16Z","timestamp":1332269416000},"page":"900-904","source":"Crossref","is-referenced-by-count":25,"title":["The Influence of Chlorhexidine on the Severity of Cyclosporin A\u2010Induced Gingival Overgrowth"],"prefix":"10.1002","volume":"68","author":[{"given":"Gibson Luiz","family":"Pilatti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Eduardo Cezar","family":"Sampaio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1997,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1997.68.9.900","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:05:47Z","timestamp":1760879147000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1997.68.9.900"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1997,9]]}},"alternative-id":["10.1902\/jop.1997.68.9.900"],"URL":"https:\/\/doi.org\/10.1902\/jop.1997.68.9.900","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,9]]}}}