{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:10:03Z","timestamp":1787771403644,"version":"build-2784847793"},"reference-count":0,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[1998,12,1]],"date-time":"1998-12-01T00:00:00Z","timestamp":912470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1998,12]]},"abstract":"<jats:p>T<jats:sc>he relationship between probing<\/jats:sc> attachment changes in treated periodontal pockets and the prevalence of selected periodontal pathogens was assessed in 10 patients with adult periodontitis 1 year following randomized therapy. All patients had at least 1 tooth in each quadrant with an inflamed pocket of probing depth \u22655 mm and clinical attachment loss and harbored at least one of the following 3 major periodontal pathogens: <jats:italic>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis<\/jats:italic>, or <jats:italic>Bacteroides forsythus<\/jats:italic>. The number of target organisms per site was determined preoperatively; at 1 week; and at 1, 3, 6, and 12 months postoperatively utilizing DNA probes. The following clinical parameters were measured and recorded preoperatively and at 1, 3, 6, and 12 months post\u2010treatment: gingival fluid flow, gingival index, plaque index, probing depth, probing attachment level, gingival recession, and bleeding on probing. One quadrant in each patient was randomly assigned to 1 of the following 4 treatments: 1) scaling and root planing; 2) pocket reduction through osseous surgery and apically\u2010positioned flap; 3) modified Widman flap; and 4) modified Widman flap and topical application of saturated citric acid at pH 1 for 3 minutes. All 4 treatments were rendered in one appointment using local anesthesia. No postoperative antibiotics were used, but patients rinsed with 0.12% Chlorhexidine for the first 3 months postoperatively and received a prophylaxis every 3 months. This investigation revealed: 1) 30.0% of the sites were infected by at least 1 species at 3, 6, and 12 months postoperatively. 2) Failing sites were infected by a high number of both <jats:italic>Pg<\/jats:italic> and <jats:italic>Bf<\/jats:italic>. These sites had a mean of 24.2 \u00b1 9.0 \u00d7 10<jats:sup>3<\/jats:sup><jats:italic>Pg<\/jats:italic> and 93.1 \u00b1 42.0 \u00d7 10<jats:sup>3<\/jats:sup> <jats:italic>Bf<\/jats:italic>, while stable sites had a mean of 6.8 \u00b1 0.5 \u00d7 10<jats:sup>3<\/jats:sup> <jats:italic>Pg<\/jats:italic> and 7.2 \u00b1 1.2 \u00d7 10<jats:sup>3<\/jats:sup> <jats:italic>Bf<\/jats:italic> (<jats:italic>P<\/jats:italic> = 0.06 and <jats:italic>P<\/jats:italic> = 0.05, respectively). 3) The infected sites lost significantly more mean clinical attachment at 12 months (1.5 \u00b1 0.5 mm compared to a loss of 0.2 \u00b1 0.3 mm for uninfected sites, <jats:italic>P<\/jats:italic> = 0.017). 4) The infected sites had a significantly greater BOP (67 \u00b1 14% versus 25 \u00b1 8% for uninfected sites at 12 months, <jats:italic>P<\/jats:italic> = 0.012). 5) The choice of treatment modality did not affect the prevalence of the target species at 1 year post\u2010treatment. These results suggest that prevalence of microbial pathogens negatively affects the 1 year outcome of periodontal surgical and nonsurgical therapy. <jats:italic>J Periodontol 1998;69:1364\u20131372<\/jats:italic>.<\/jats:p>","DOI":"10.1902\/jop.1998.69.12.1364","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T12:47:46Z","timestamp":1332247666000},"page":"1364-1372","source":"Crossref","is-referenced-by-count":13,"title":["The Prevalence of <i>Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis<\/i>, and <i>Bacteroides forsythus<\/i> in Humans 1 Year After 4 Randomized Treatment Modalities"],"prefix":"10.1002","volume":"69","author":[{"given":"Jacob","family":"Shiloah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R.","family":"Patters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"John W.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Bland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Toledo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1998,12]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1998.69.12.1364","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:22:46Z","timestamp":1760880166000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1998.69.12.1364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,12]]},"references-count":0,"journal-issue":{"issue":"12","published-print":{"date-parts":[[1998,12]]}},"alternative-id":["10.1902\/jop.1998.69.12.1364"],"URL":"https:\/\/doi.org\/10.1902\/jop.1998.69.12.1364","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,12]]}}}