{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:25:56Z","timestamp":1771550756487,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1998,9,1]],"date-time":"1998-09-01T00:00:00Z","timestamp":904608000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1998,9]]},"abstract":"<jats:p>T<jats:sc>he periodontal pathogen<\/jats:sc> <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> produces a leukotoxin that is considered a primary virulence factor in localized juvenile periodontitis (LJP). Select strains of the bacterium contain a 530\u2010bp deletion in the promoter region of the leukotoxin gene operon which results in enhanced transcription of the leukotoxin. DNA hybridization and polymerase chain reaction (PCR) were used to examine genetic variants of <jats:italic>A. actinomycetemcomitans<\/jats:italic> in 24 LJP\u2010susceptible children from 21 families having a history of the disease and 34 control children from non\u2010LJP families. A significant association was found between the detection of variants that had a deletion in the leukotoxin promoter region, indicative of a high level expression leukotoxin genotype, and conversion from a healthy periodontal status to disease. Subjects harboring <jats:italic>A. actinomycetemcomitans<\/jats:italic> of this genotype were more likely to convert to LJP than those subjects who had variants containing the full length leukotoxin promoter region (odds ratio = 22.50, 95% C.I.). These findings support the concept that highly virulent strains or clonai types of periodontal pathogens play a major role in the initiation of periodontal disease in susceptible hosts. <jats:italic>J Periodontol 1998;69:998\u20131007.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1998.69.9.998","type":"journal-article","created":{"date-parts":[[2012,3,20]],"date-time":"2012-03-20T14:27:40Z","timestamp":1332253660000},"page":"998-1007","source":"Crossref","is-referenced-by-count":87,"title":["Relationship Between Conversion of Localized Juvenile Periodontitis\u2010Susceptible Children From Health to Disease and <i>Actinobacillus actinomycetemcomitans<\/i> Leukotoxin Promoter Structure"],"prefix":"10.1002","volume":"69","author":[{"given":"Lina C.","family":"Bueno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia P.A.","family":"Mayer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph M.","family":"DiRienzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1998,9]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1998.69.9.998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1998.69.9.998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:58:28Z","timestamp":1760864308000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1998.69.9.998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,9]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1998,9]]}},"alternative-id":["10.1902\/jop.1998.69.9.998"],"URL":"https:\/\/doi.org\/10.1902\/jop.1998.69.9.998","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,9]]}}}