{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:47:54Z","timestamp":1790912874008,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[1999,10,1]],"date-time":"1999-10-01T00:00:00Z","timestamp":938736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1999,10]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The periodontal status of 41 medically healthy adults with untreated chronic periodontitis was monitored before and after scaling and root planing (SRP).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> During a 6\u2010month pretreatment phase, clinical measurements, digital subtraction radiography (DSR) analysis of alveolar bone, and measurement of gingival crevicular fluid (GCF) prostaglandin E<jats:sub>2<\/jats:sub> (PGE<jats:sub>2<\/jats:sub>) levels were undertaken. SRP was provided during a 1\u2010month treatment phase. Clinical, radiographic, and biochemical analyses were repeated in a 6\u2010month post\u2010treatment healing period.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Pretreatment: no clinically significant changes in mean plaque indices (PI), probing depths (PD), bleeding on probing (BOP), or relative clinical attachment levels (CAL) were detected (<jats:italic>P<\/jats:italic> &gt;0.05). DSR revealed small but statistically significant bone height (0.04 mm) and mass (0.97 mg) loss (<jats:italic>P<\/jats:italic> &lt;0.001). GCF PGE<jats:sub>2<\/jats:sub> levels gradually increased from 38.8 ng\/ml at month 1 to 79.4 ng\/ml at month 6. Post\u2010treatment: statistically and clinically significant reductions were observed in mean PI, BOP, and PD (<jats:italic>P<\/jats:italic> &lt;0.05). A statistically significant reduction in CAL was noted (<jats:italic>P<\/jats:italic> &lt;0.05). The trend towards progressive bone loss was halted and reversed, and a statistically significant decrease in GCF PGE<jats:sub>2<\/jats:sub> concentrations was detected (<jats:italic>P<\/jats:italic> &lt;0.001). Smokers, non\u2010smokers, and ex\u2010smokers did not differ significantly in PI, BOP, CAL, radiographic, or biochemical parameters at any time. Mean PD was significantly greater in current smokers than in non\u2010 and ex\u2010smokers (<jats:italic>P<\/jats:italic> &lt;0.005). PD reduced comparably in all 3 smoking subgroups following treatment (<jats:italic>P<\/jats:italic> &lt;0.01).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Conventional clinical measurements failed to identify disease progression over a 6\u2010month period. Significant improvements were observed in clinical parameters after SRP, and a trend towards progressive bone loss was halted and reversed. Regular and frequent maintenance visits are important following treatment to maintain improvements in clinical parameters. Smokers had deeper probing depths than non\u2010 and ex\u2010smokers, but pockets were reduced significantly and comparably in all 3 smoking subgroups following efficacious treatment. <jats:italic>J Periodontol 1999;70:1209\u20101220.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1999.70.10.1209","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:00:28Z","timestamp":1107324028000},"page":"1209-1220","source":"Crossref","is-referenced-by-count":44,"title":["Progression and Treatment of Chronic Adult Periodontitis"],"prefix":"10.1002","volume":"70","author":[{"given":"Philip M.","family":"Preshaw","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Lauffart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Zak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie K.","family":"Jeffcoat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Barton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Heasman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1999.70.10.1209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:57:26Z","timestamp":1760878646000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1999.70.10.1209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[1999,10]]}},"alternative-id":["10.1902\/jop.1999.70.10.1209"],"URL":"https:\/\/doi.org\/10.1902\/jop.1999.70.10.1209","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,10]]}}}