{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T23:07:40Z","timestamp":1785366460507,"version":"3.55.0"},"reference-count":0,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[1999,6,1]],"date-time":"1999-06-01T00:00:00Z","timestamp":928195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> A standard treatment strategy for periodontal infections often consists of 4 consecutive sessions of scaling and root planing (per quadrant, at 1\u2010 to 2\u2010week intervals), without proper disinfection of the remaining intra\u2010oral niches for periodontopathogens. This could theoretically lead to a reinfection of previously disinfected pockets by bacteria from an untreated region\/niche. This study aimed to investigate, over an 8\u2010month period, the clinical benefits of a one stage full\u2010mouth disinfection in the control of severe periodontitis.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Sixteen patients with early\u2010onset periodontitis and 24 patients with severe adult periodontitis were randomly assigned to test and control groups. The control group was scaled and root planed, per quadrant, at 2\u2010week intervals and given standard oral hygiene instructions. A one stage full\u2010mouth disinfection (test group) was sought by scaling and root planing the 4 quadrants within 24 hours in combination with the application of chlorhexidine to all intra\u2010oral niches for periodontopathogens. Besides oral hygiene, the test group also rinsed twice daily with a 0.2% chlorhexidine solution and sprayed the tonsils with a 0.2% chlorhexidine spray, for 2 months. The plaque index, gingival index, probing depth, bleeding on probing, gingival recession, and clinical attachment level were recorded at baseline and at 1, 2, 4, and 8 months afterwards.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The one stage full\u2010mouth disinfection resulted, in comparison to the standard therapy, in a significant (<jats:italic>P<\/jats:italic> &lt;0.001) additional probing depth reduction and gain in attachment up to 8 months. For initial pockets \u22657 mm, the \u201cadditional\u201d probing depth reduction at the 8 month follow\u2010up was 1.2 mm for single\u2010rooted and 0.9 mm for multi\u2010rooted teeth, with corresponding additional gains in attachment of 1.0 mm and 0.8 mm, respectively. The additional improvements were observed for all subgroups (adult periodontitis, generalized early\u2010onset cases, smokers), with the largest differences in the non\u2010smoking adult periodontitis patients.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> These findings suggest that a one stage full\u2010mouth disinfection results in an improved clinical outcome for the treatment of chronic adult or early\u2010onset periodontitis as compared to scaling and root planing per quadrant at 2\u2010week intervals. <jats:italic>J Periodontol 1999;70:632\u2010645.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1999.70.6.632","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:10:57Z","timestamp":1107324657000},"page":"632-645","source":"Crossref","is-referenced-by-count":117,"title":["One Stage Full\u2010 Versus Partial\u2010Mouth Disinfection in the Treatment of Chronic Adult or Generalized Early\u2010Onset Periodontitis. I. Long\u2010Term Clinical Observations"],"prefix":"10.1002","volume":"70","author":[{"given":"Claudio","family":"Mongardini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"van Steenberghe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christel","family":"Dekeyser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Quirynen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1999,6]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1999.70.6.632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T08:41:13Z","timestamp":1760863273000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1999.70.6.632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":0,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1999,6]]}},"alternative-id":["10.1902\/jop.1999.70.6.632"],"URL":"https:\/\/doi.org\/10.1902\/jop.1999.70.6.632","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}