{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:35:09Z","timestamp":1762374909034,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1999,8,1]],"date-time":"1999-08-01T00:00:00Z","timestamp":933465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[1999,8]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Whether adjunctive tetracycline fibers can provide an additive effect to scaling and root planing in treating non\u2010responsive sites in maintenance subjects is still controversial. Recolonization of the bacteria from untreated sites or from the extracrevicular region may explain the insignificant response to local therapy. The purpose of the present study was to evaluate the microbiological response of sites treated with tetracycline fibers combined with scaling and root planing.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> The study was conducted in a split\u2010mouth design. Thirty patients on maintenance therapy having at least 2 non\u2010adjacent sites in separate quadrants with probing depths between 4 to 8 mm with bleeding on probing, or aspartate aminotransferase enzyme levels &gt; 800 \u03bclU in the gingival crevicular fluid, were treated with scaling and root planing plus tetracycline fibers or with scaling and root planing only. Subgingival plaque samples were collected at baseline, and 1, 3, and 6 months following treatment. <jats:italic>A. actinomycetemcomitans, C. rectus, B. forsythus, E. corrodens, F. nucleatum, P. gingivalis,<\/jats:italic> and <jats:italic>P. intermedia <\/jats:italic>were detected by culture, immunofluorescence, or PCR technique.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> There was a reduction of total bacterial cell count, as well as of certain periodontal pathogens, following treatment. The prevalence of <jats:italic>A. actinomycetemcomitans, B. forsythus,<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> and the mean proportions of <jats:italic>C. rectus, P. intermedia, F. nucleatum,<\/jats:italic> and <jats:italic>P. gingivalis<\/jats:italic> decreased after therapy, but there was no statistically significant difference between the 2 treatment groups with respect to bacterial proportions or the number of positive sites. Besides, the pathogens could not be eliminated from the periodontal pocket, and recolonization of the pocket was noted at 3 months post\u2010treatment.<\/jats:p><jats:p><jats:bold>Conclusions: <\/jats:bold>Bacteria located within the cheek, tongue mucosa, saliva, or untreated sites may contribute to reinfection of the pockets and explain the insignificant response to local tetracycline therapy. <jats:italic>J Periodonto1 1999;70:861\u2010868.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.1999.70.8.861","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:12:12Z","timestamp":1107324732000},"page":"861-868","source":"Crossref","is-referenced-by-count":24,"title":["Microbiological Response of Localized Sites with Recurrent Periodontitis in Maintenance Patients Treated with Tetracycline Fibers"],"prefix":"10.1002","volume":"70","author":[{"given":"Man\u2010Ying","family":"Wong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chia\u2010Lin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheing\u2010Meei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lein\u2010Tuan","family":"Hou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1999,8]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.1999.70.8.861","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T12:01:15Z","timestamp":1760875275000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.1999.70.8.861"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1999,8]]}},"alternative-id":["10.1902\/jop.1999.70.8.861"],"URL":"https:\/\/doi.org\/10.1902\/jop.1999.70.8.861","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[1999,8]]}}}