{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T20:05:47Z","timestamp":1778357147513,"version":"3.51.4"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The aim of this study was to determine the distribution patterns of <jats:italic>Porphyromonas gingivalis, Prevotella intermedia\/nigrescens,<\/jats:italic> and <jats:italic>Actinobacillus actinomycetemcomitans<\/jats:italic> in periodontitis patients after standard mechanical periodontal therapy, and to determine factors increasing the odds to detect these target organisms in treated sites.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Eight hundred fifty\u2010two (852) separate subgingival microbial samples were taken from the mesial and distal aspects of every tooth in 17 patients. Target organisms were identified culturally.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> The 3 microorganisms showed different persistence patterns: <jats:italic>P. gingivalis<\/jats:italic> was detected in a high percentage of subjects (59%), but in a low proportion of sites (5.4%). <jats:italic>P. intermedia\/nigrescens<\/jats:italic> was detected in all subjects except one, and in 40.6% of the tested sites. Only 5 subjects were <jats:italic>A. actinomycetemcomitans<\/jats:italic> positive, but 2 of them showed a very high number of positive sites (44% and 75%, respectively). A highly significant relationship was found between a subject's tendency to bleed upon sampling and the number of <jats:italic>P. intermedia\/nigrescenspositive<\/jats:italic> sites. A significant portion of the variation in frequency of persisting <jats:italic>P. gingivalis<\/jats:italic> could be explained by the frequency of persisting pockets deeper than 4 mm. No similar relationship could be established between clinical parameters and <jats:italic>A. actinomycetemcomitans<\/jats:italic>. On a site level, the odds of detecting <jats:italic>P. gingivalis<\/jats:italic> increased by a factor of 2.47 (<jats:italic>P<\/jats:italic> = 0.0001) for every millimeter of residual probing depth; the odds of detecting <jats:italic>P. intermedia\/nigrescens<\/jats:italic> increased by a factor of 1.84 (<jats:italic>P<\/jats:italic> = 0.0001).<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> If, after standard mechanical periodontal therapy, a large number of sites continue to bleed, one may expect an increased number of sites positive for<jats:italic> P. intermedia\/nigrescens<\/jats:italic>. If many deep pockets persist, a greater number of <jats:italic>P. gingivalis<\/jats:italic>\u2010positive sites can be expected. <jats:italic>J Periodontol 2000; 71:14\u201021.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2000.71.1.14","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:16:43Z","timestamp":1107325003000},"page":"14-21","source":"Crossref","is-referenced-by-count":133,"title":["Persistence Patterns of <i>Porphyromonas gingivalis, Prevotella intermedia\/ nigrescens,<\/i> and <i>Actinobacillus actinomycetemcomitans<\/i> After Mechanical Therapy of Periodontal Disease"],"prefix":"10.1002","volume":"71","author":[{"given":"Andrea","family":"Mombelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Rutar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.1.14","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:42:56Z","timestamp":1760881376000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.1.14"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1902\/jop.2000.71.1.14"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.1.14","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}