{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:42:22Z","timestamp":1760920942355,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Hyperplastic gingival tissues show the histopathological characteristics of thick parakeratinized squamous epithelia with acanthosis and rete pegs elongated into the lamina propria. However, the pathogenic factors that contribute to the epithelial morphogenesis of this disease are obscure and remain to be studied.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We immunohistochemically examined the expression of both c\u2010Myc and bcl\u20102 oncoprotein, which can exert influence on the epithelial morphogenesis and homeostasis, in 12 hyperplastic gingival tissues induced by nifedipine and phenytoin as well as 5 control tissues using avidin\u2010biotin\u2010peroxidase complex methods.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Four specimens out of 5 nifedipine\u2010induced and 5 out of 7 phenytoin\u2010induced hyperplastic gingival tissues revealed the expression of c\u2010Myc oncoprotein, whereas no significant immunostaining of c\u2010Myc oncoprotein was found in 5 control tissues. The c\u2010Myc oncoprotein\u2010positive cells were observed to be localized in the basal and suprabasal cell layers of the hyperplastic gingival epithelia. Although all of the 12 hyperplastic gingival epithelia showed the distribution of bcl\u20102 oncoprotein in the basal and suprabasal layer cells, in 5 control epithelia the bcl\u20102 oncoprotein expression was slight and confined to the basal layer cells.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> The results of our present study indicate that the synergistic overexpression of c\u2010Myc and bcl\u20102 oncoprotein may be related to the pathogenesis of gingival hyperplasia induced by nifedipine and phenytoin, especially to the morphogenesis of hyperplastic epithelia. <jats:italic>J Periodontol 2000;71:44\u201049.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2000.71.1.44","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:16:43Z","timestamp":1107325003000},"page":"44-49","source":"Crossref","is-referenced-by-count":12,"title":["Immunolocalization of c\u2010Myc and bcl\u20102 Proto\u2010Oncogene Products in Gingival Hyperplasia Induced by Nifedipine and Phenytoin"],"prefix":"10.1002","volume":"71","author":[{"given":"Keiichi","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Mori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Tanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seizaburo","family":"Sakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.1.44","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:42:55Z","timestamp":1760881375000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.1.44"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1902\/jop.2000.71.1.44"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.1.44","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}