{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:19:09Z","timestamp":1791134349061,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,1]]},"abstract":"\n Background:<\/jats:bold>\n The prevailing concept is that little or no clear benefit is derived from antibiotic therapy in chronic periodontitis. Studies to determine the effect of metronidazole plus amoxicillin (M+A) on adult periodontitis are questionable because standard design for clinical trials was usually not used. In addition, there is no information about the effect of M+A as the sole therapy for periodontitis.\n <\/jats:p>\n \n Methods:<\/jats:bold>\n A randomized, triple\u2010blind, controlled clinical trial was used to determine the effect of systemic administration of M+A, as the sole therapy, in progressive adult periodontitis. Forty\u2010six subjects with moderate to advanced adult periodontitis who showed \u22652 mm attachment loss in at least 2 sites in the previous 2 months were entered in the study. Subjects were randomly distributed to a group who received 21 tablets of metronidazole 250 mg plus amoxicillin 500 mg, or to a group receiving a placebo (1 tablet every 8 hours for 1 week). Patients were examined every 2 months for 12 months. The M+A or placebo regimen was repeated at 4 and 8 months. No effort was made to change the oral habits of patients and they received no additional therapy. Differences between groups were assessed using the Mann\u2010Whitney U test. The differences at every 2\u2010month interval within each group were assessed using the ANOVA test.\n <\/jats:p>\n \n Results:<\/jats:bold>\n Seven subjects abandoned the study; at 12 months the M+A group had 20 subjects and the placebo group 19. There were no significant differences in the clinical parameters at baseline between the 2 groups. After 2 months and thereafter, the M+A group showed significant clinical improvement while the placebo group showed a progressive deterioration of periodontal status. At 12 months compared to baseline, subjects of the M+A group showed: 1) a significant overall mean attachment gain of 0.43 mm (\n P<\/jats:italic>\n = 0.005); 2) a significant decrease of active sites (\n P<\/jats:italic>\n \u22640.03); 3) a significant increase of sites gaining attachment level (\n P<\/jats:italic>\n \u22640.01); 4) a significant reduction of pocket depth (\n P<\/jats:italic>\n \u22640.00006); and 5) a significant decrease in percentage of bleeding on probing sites (BOP) (\n P<\/jats:italic>\n \u22640.0005). Significant differences between both groups at all 2\u2010month evaluations were found in overall mean attachment level (\n P<\/jats:italic>\n \u22640.000004), in percent of active sites (\n P<\/jats:italic>\n \u22640.03), and in percent of BOP sites (\n P<\/jats:italic>\n \u22640.02). Sites exhibiting \u22652 mm of attachment loss in 2 successive or alternate evaluations, and periodontal abscess were noticed only in the placebo group.\n <\/jats:p>\n \n Conclusions:<\/jats:bold>\n A 1\u2010week course of systemic M+A every 4 months, as the only therapy, arrests the progression of adult periodontitis and significantly improves the clinical parameters of the disease.\n J Periodontol 2000;71:79\u201089.<\/jats:italic>\n <\/jats:p>","DOI":"10.1902\/jop.2000.71.1.79","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:16:43Z","timestamp":1107325003000},"page":"79-89","source":"Crossref","is-referenced-by-count":47,"title":["Repeated Metronidazole and Amoxicillin Treatment of Periodontitis. A Follow\u2010Up Study"],"prefix":"10.1002","volume":"71","author":[{"given":"N\u00e9stor J.","family":"L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge A.","family":"Gamonal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,1]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.1.79","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T13:42:54Z","timestamp":1760881374000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.1.79"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,1]]}},"alternative-id":["10.1902\/jop.2000.71.1.79"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.1.79","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,1]]}}}