{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:13:56Z","timestamp":1791584036903,"version":"4.3.4"},"reference-count":0,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2000,10,1]],"date-time":"2000-10-01T00:00:00Z","timestamp":970358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:p>\n                    <jats:bold>Background:<\/jats:bold>\n                    Periodontitis is a common, often undiagnosed, chronic infection of the supporting tissues of the teeth, epidemiologically associated with cardiovascular diseases. Since Creactive protein (CRP) and other systemic markers of inflammation have been identified as risk factors for cardiovascular diseases, we investigated whether these factors were elevated in periodontitis.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods:<\/jats:bold>\n                    Consecutive adult patients with periodontitis (localized n = 53; generalized n = 54), and healthy controls (n = 43), all without any other medical disorder, were recruited and peripheral blood samples were taken.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results:<\/jats:bold>\n                    Patients with generalized periodontitis and localized periodontitis had higher median CRP levels than controls (1.45 and 1.30 versus 0.90 mg\/L, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.030); 52% of generalized periodontitis patients and 36% of the localized periodontitis patients were sero\u2010positive for interleukin\u20106 (IL\u20106), compared to 26% of controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.008). Plasma IL\u20106 levels were higher in periodontitis patients than in controls (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.015). Leukocytes were also elevated in generalized periodontitis (7.0 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L) compared to localized periodontitis and controls (6.0 and 5.8 \u00d7 10\n                    <jats:sup>9<\/jats:sup>\n                    \/L, respectively,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.002); this finding was primarily explained by higher numbers of neutrophils in periodontitis (\n                    <jats:italic>p<\/jats:italic>\n                    = 0.001). IL\u20106 and CRP correlated with each other, and both CRP and IL\u20106 levels correlated with neutrophils. The current findings for periodontitis were controlled for other known factors associated with cardiovascular diseases, including age, education, body mass index, smoking, hypertension, cholesterol, and sero\u2010positivity for CMV,\n                    <jats:italic>Chlamydia pneumoniae<\/jats:italic>\n                    , and\n                    <jats:italic>Helicobacter pylori.<\/jats:italic>\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions:<\/jats:bold>\n                    Periodontitis results in higher systemic levels of CRP, IL\u20106, and neutrophils. These elevated inflammatory factors may increase inflammatory activity in atherosclerotic lesions, potentially increasing the risk for cardiac or cerebrovascular events.\n                    <jats:italic>J Periodontol 2000;71:1528\u20101534.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1902\/jop.2000.71.10.1528","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:18:58Z","timestamp":1107325138000},"page":"1528-1534","source":"Crossref","is-referenced-by-count":560,"title":["Elevation of Systemic Markers Related to Cardiovascular Diseases in the Peripheral Blood of Periodontitis Patients"],"prefix":"10.1002","volume":"71","author":[{"given":"Bruno G.","family":"Loos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Craandijk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Hoek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulien M.E. Wertheim\u2010van","family":"Dillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ubele","family":"Van Der Velden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2000,10]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.10.1528","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:06:40Z","timestamp":1760864800000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.10.1528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":0,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1902\/jop.2000.71.10.1528"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.10.1528","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"value":"0022-3492","type":"print"},{"value":"1943-3670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}