{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:21:42Z","timestamp":1760919702055,"version":"build-2065373602"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,3,1]],"date-time":"2000-03-01T00:00:00Z","timestamp":951868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Periodontology"],"published-print":{"date-parts":[[2000,3]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> Patients receiving an HLA\u2010matched bone marrow transplant (BMT) from a relative or unrelated donor undergo a permanent alteration of their immune system, followed by a prolonged period of immunodeficiency. This study aimed to examine alterations in the periodontal status of patients over 6 months post\u2010bone marrow transplantation.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Thirty\u2010seven patients scheduled for bone marrow transplantation participated in this study. One calibrated examiner carried out periodontal examinations (clinical and radiographic) immediately prior to and at 3 and 6 months after transplantation. All patients followed an intense oral care program. Subgingival plaque samples were analyzed by enzyme\u2010linked immunosorbent assay (ELISA) for the presence of <jats:italic>Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, and Prevotella intermedia.<\/jats:italic> Data were subjected to statistical analyses to determine the relationships between the frequency distribution of the radiographic and clinical variables over time.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Gains in clinical attachment level (CAL) of \u22642 mm at 4 or more sites from baseline to 6 months post\u2010BMT were noted in 9\/16 patients (56%), while 6\/16 (38%) patients experienced a loss of CAL \u22642 mm at 4 or more sites in the same period. At a site level, 4.8% of sites exhibited a gain in CAL \u22642 mm between baseline and 3 months post\u2010BMT while 2.3% of sites showed a loss of CAL \u22642 mm in the same period. From baseline to 6 months, a gain in CAL of \u22642 mm was recorded at 3.1% of sites, and 2.4% of sites experienced a loss of \u2264mm. A significant improvement in the gingival index occurred between all sequential time periods when assessed at a site level. At a patient level, 11\/18 (61%) patients showed a significant change in gingival index between baseline and 3 months and 10\/16 (63%) between baseline and 6 months. There was no significant relationship between clinical changes and the prevalence of the periodontal pathogens at the various time periods.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> An improvement in periodontal health was recorded between baseline and 6 months post\u2010transplantation. Most of the improvement in periodontal status was noted in the first 3 months after BMT, with a slight decline in periodontal health between 3 and 6 months post\u2010transplant. No significant alteration was noted in the prevalence of periodontal pathogens during the study period. <jats:italic>J Periodontol 2000;71:394\u2010402.<\/jats:italic><\/jats:p>","DOI":"10.1902\/jop.2000.71.3.394","type":"journal-article","created":{"date-parts":[[2005,2,2]],"date-time":"2005-02-02T06:28:11Z","timestamp":1107325691000},"page":"394-402","source":"Crossref","is-referenced-by-count":20,"title":["Changes in the Periodontal Status of Patients Undergoing Bone Marrow Transplantation"],"prefix":"10.1002","volume":"71","author":[{"given":"R.","family":"Pattni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.J.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.I.","family":"Marshall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.P.","family":"Cullinan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.J.","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Bartold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2000,3]]},"container-title":["Journal of Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/pdf\/10.1902\/jop.2000.71.3.394","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T09:02:48Z","timestamp":1760864568000},"score":1,"resource":{"primary":{"URL":"https:\/\/aap.onlinelibrary.wiley.com\/doi\/10.1902\/jop.2000.71.3.394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,3]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000,3]]}},"alternative-id":["10.1902\/jop.2000.71.3.394"],"URL":"https:\/\/doi.org\/10.1902\/jop.2000.71.3.394","archive":["Portico"],"relation":{},"ISSN":["0022-3492","1943-3670"],"issn-type":[{"type":"print","value":"0022-3492"},{"type":"electronic","value":"1943-3670"}],"subject":[],"published":{"date-parts":[[2000,3]]}}}